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Branched-chain amino acid metabolism: novel targets and interaction pathways
Unmet Need Branched chain amino acids (BCAA) leucine, isoleucine, and valine are essential for human health. However, BCAA are also known to be strongly elevated in the context of metabolic disease such as obesity, type…
MEWS: a clinical model to predict probability of maternal sepsis trigger in obstetrics patients
Unmet Need Sepsis is a life-threatening emergency characterized by an overactive and improper inflammatory response by the body to an infection or injury leading to tissue damage, organ failure and death if not treated promptly.…
RXR modulators to improve the efficacy of immunomodulatory agents in multiple myeloma treatment
Unmet Need Multiple myeloma (MM) is the second most common hematological malignancy in the United States. Although current anti-myeloma therapeutics help patients live with the disease for more than 10 years, MM remains an incurable…
Olfactory neuroblastoma mouse model
Unmet Need Olfactory neuroblasoma (ONB) is an agressive tumor that is thought to arise in basal stem cells in the adult olfactory epithelium. This rare cancer affects 1 in 2.5 million people each year with…
iPSC line to identify novel therapies for ARVC
Technology Duke inventors have developed a novel induced pluripotent stem cell (iPSC) line that contains a mutation that impacts the TAX1BP3 gene, which causes arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC). Specifically, the iPSCs were derived from…
Transgenic zebrafish to direct epicardial gene expression
Technology Duke inventors have generated a novel zebrafish model that allows researchers to study epicardial cells during embryonic heart development and myocardial regeneration. This zebrafish line is termed Tg(tcf21:CreER)pd42. Specifically, this transgenic model was created…
Plasmids with RNA aptamers to B-arrestin
Technology Duke inventors have created 10 novel plasmids which can be used for the production of RNA aptamers to β-arrestins through in vitro translation: pCR-TOPO-8R1-36 pCR-TOPO-8R2-1 pCR-TOPO-8R2-15 pCR-TOPO-8R2-16 pCR-TOPO-8R2-20 pCR-TOPO-8R2-21 pCR-TOPO-8R2-24 pCR-TOPO-11R2-5 pCR-TOPO-11R2-7 pCR-TOPO-11R2-15
Plasmids for the expression of B-arrestins and GRKs
Technology Duke inventors have generated 12 novel plasmids that can be used for the expression of β-arrestins and GRKs: pCDNA3-βarrestin1-Flag pCDNA3-βarrestin2-Flag pGEX-5G/LIC-βarrestin1 pGEX-5G/LIC-βarrestin2 pGEX-4T1-βarrestin1 C-terminus pGEX-4T1-βarrestin2 C-terminus pRK5-bGRK2 pRK5-bGRK3 pRK5-bGRK4 pRK5-hGRK5 pRK5-hGRK6 pRK5-hGRK26caax
B-arrestin biosensor cell lines
Technology Duke inventors have created 14 novel biosensor cell lines that can be used for the detection of translocation events, generation of signaling messages, and protein-protein interactions within cells: U2OS-βarrestin2-YFP U2OS-βarrestin1-YFP 293-βarrestin2-YFP 293-βarrestin1-YFP NIH-3T3-Smo-GFP HEK293-rATlaR-CFP,…
B-arrestin 1 and 2 conditional knockout mouse models
Technology Duke inventors have created two novel mouse lines for the acute ablation of β-arrestin 1 or β-arrestin 2: Conditional Flox/Cre (tet inducible) β-arrestin 1 KO mice (C57/BL6J background) Conditional Flox/Cre (tet inducible) β-arrestin 2…
Cell lines for the overexpression of GPCRs
Technology Duke inventors have generated five novel cell lines that can be used for the stable overexpression of several GPCRs: HEK293-rATlaR (2pM/mg) HEK293-rATlaR (600fM/mg) NIH-3T3-Flag-Smo 1.1 NIH-3T3-Flag-Smo 1.7 HEK293-Flag-β2AR (2pM/mg, W9)
Plasmids for the overexpression of GPCRs
Technology Duke inventors have generated four novel GPCR plasmids that can be used for the stable overexpression of several GPCRs: pcDNA3-Flag-β2AR pcDNA3-hAT1R (human) pcDNA3-HA-rATlaR (rat) pcDNA3-Flag-rATlaR (rat)