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A drug-infused hydrogel implant for glaucoma drainage devices
Unmet Need Glaucoma is an ocular disease involving heightened eye pressure most commonly leading to blindness, affecting roughly 3 million Americans. Current treatments include anti-steroidal or anti-inflammatory drugs to remove excess ocular fluid or decrease…
Wearable smart radiation reporting material
Unmet Need Excess radiation exposure can result in DNA damage and tissue injury. Individuals who are occupationally exposed to ionizing radiation need to monitor and track radiation exposures. Small, personal radiation dosimeters currently exist, but…
T-cell releasing antibody for breast cancer tumor metastasis prevention
Unmet Need Metastatic breast cancer is a deadly form of breast cancer with only 1/3 of patients diagnosed with it living to 5 years post-diagnosis. Metastasis can occur either at disease onset (6% of patients)…
Small molecule inhibitors of eHSP90 to treat autoimmune diseases
Unmet Need It is estimated that autoimmune diseases affect 1 out of every 10 individuals. These debilitating diseases are the result of the immune system inappropriately targeting and attacking the body. The resulting disease is…
Collection of novel CRISPR guide RNAs and their creation method
Unmet Need The advent of CRISPR-Cas9 technology has enabled targeted rapid modification of genes and sparked a biotechnology revolution. The CRISPR-Cas9 complex is composed of two parts: a guide RNA specific to the DNA sequence…
Method to express olfactory receptors for ultra-high sensitivity detection of odorants and other volatile chemicals
Unmet Need Artificial sensors for sight and sound are so ubiquitous that we frequently take them for granted. Whenever we ask Siri, join a conference call, or walk through an automatic door we benefit from…
A method for end-to-end spatial accuracy quality assurance for radiosurgery
Unmet Need Radiation therapy is an essential element of cancer treatment that benefits 4 million diagnosed patients every year. The ability to deliver complex three-dimensional distributions of dose that conform to even irregularly shaped lesions…
A method for reducing speckle and improving resolution in ultrasound imaging
Value Proposition For many years, ultrasound imaging has been an important and popular medical imaging method. The speckle texture in ultrasound images limits the detectability of low contrast targets. With size on the order of…
Leukocyte phenotyping methods to provide prognostic information and risk/resilience stratification for surgical procedures and critical illness
Unmet Need It is estimated that surgical complications arise in 16.4%, or almost 1 in 6 surgical procedures in the United States. Most complications have an immunological basis related to infection or aberrant adaptation to…
Novel epigenetic therapy for Prader Willi Syndrome
Unmet Need Prader-Willi Syndrome (PWS) is a rare and complex genetic disorder affecting an estimated 1 in 10,000 to 30,000 infants. Primarily caused by a paternal chromosome 15q11-q13 deletion, PWS presents a myriad of physical,…
Connecting cardiac and respiratory 3DCT imaging for 5DCT heart motion management
Unmet Need Ventricular tachycardia (VT) is a primary condition of heart disease noted as an irregularity of heart rhythm due to improper electrical signaling in the ventricles that causes an abnormally high heart rate. VT…
A functionally selective ghrelin receptor (GHSR) ligand for treatment of chemical and food addiction
Unmet Need The number of Americans with addiction-related disorders, including substance use disorders (SUD) and food addiction is increasing rapidly each year. Recent estimates indicate that >20 million people in the U.S. have been diagnosed…