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Method to improve durability of polymer networks of crosslinked elastomers
Unmet Need The lifespan of polymer materials is limited by premature failure due to poor mechanical properties such as toughness. Increased polymer toughness enhances material performance by improving its ability to absorb stress before breaking,…
Targeted SNCA Downregulation for Parkinson’s and Synucleinopathies
Unmet Need Parkinson’s disease (PD) is the second most common neurodegenerative disorder, affecting approximately 10 million people globally and 1 million in the U.S. The disease is characterized by involuntary movements such as tremors, stiffness,…
Permanent blood pressure control through liver-directed gene editing
Unmet Need The World Health Organization estimates that high blood pressure (hypertension) results in approximately 9 million annual deaths worldwide. While current medications can lower blood pressure, they are limited by the need for lifelong…
Schenk Composer: A framework for algorithmic music generation
Unmet Need Music composition remains largely inaccessible to individuals without formal training in music theory, despite growing interest in AI-assisted creative tools. Existing AI-generated music solutions frequently produce results that are uninterpretable and unpredictable, offering…
High-speed 3D tomographic imaging using a camera array
Unmet Need Tomographic imaging has revolutionized both scientific research and clinical procedures. 3D tomographic imaging reveals information about a sample’s volume, depth, and internal structures, which cannot be obtained from 2D imaging alone. However, 3D…
GPR37 and GPR37L1 Agonists for Non-Addictive Pain Resolution in Inflammatory and Neuropathic Pain
Unmet Need Chronic pain remains a widespread clinical issue, with existing treatments primarily focused on symptom suppression rather than addressing the biological mechanisms driving pain persistence. Opioids and NSAIDs provide temporary relief but fail to…
PD-L1-Based Therapy for Non-Opioid Treatment of Chronic Pain
Unmet Need Chronic pain, including inflammatory, neuropathic, and cancer-related pain, remains difficult to manage without opioids, which pose risks of addiction and adverse side effects. Existing non-opioid treatments often fail to provide sufficient relief or…
TGF-β1-Secreting Bone Marrow Stromal Cell Therapy for Long-Lasting Neuropathic Pain Relief
Unmet Need Neuropathic pain remains a significant clinical challenge, with current treatments providing only temporary relief and failing to address the underlying neuroinflammatory mechanisms. Chronic nerve injury leads to persistent pain hypersensitivity, which is difficult…
Auto-aligning slit lamp for eye exams
Unmet Need At least 2.2 billion people in the world have vision impairment. In 2019, there were 60 million incident cases and 438.4 thousand years lived with disability of eye injury. Almost half of these…
Auto-aligning handheld optical coherence tomography probe
Unmet Need Optical coherence tomography (OCT) is an optical imaging modality that uses low-coherence light to non-invasively obtain high resolution ocular images of structures including the retina and optic nerve. OCT has advantages over other…
Microbial Growth Foundational Model
Unmet Need Microbial growth dynamics provide crucial insights into microbial populations, with applications in drug discovery, personalized medicine, and synthetic biology. Advances in the field have resulted in an ever-growing list of known microbe species…
Combat-Ready Pelvic Hemorrhage Stabilization: Lightweight Tourniquet-Extending Canteen Cover (TECC) for Junctional Wounds
Unmet Need Uncontrolled junctional hemorrhage, particularly in the pelvic region, is responsible for one in four potentially survivable military deaths. These injuries are frequently sustained from penetrating wounds in combat, and standard tourniquets are ineffective…