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Recycled error bits: architectural support for energy-efficient and numerically accurate software
Value proposition Computer perform extensive amount of calculations which is carried out by the floating point hardware. The finite precision of floating point hardware provides a potential for small inaccuracies to result in larger, glaring…
Subscription based MIMO wireless power tranmission
Subscription based multiple-input-single-output and multiple-input-multiple-output wireless energy transfer enables selective charging and powering of mobile devices using a plurality of spatially distributed transmitters that are synchronized under the control of a transmitter controller. Amplitude, phase,…
Genes involved in the pathogenesis of anxiety disorders including obsessive-compulsive disorder
Anxiety disorders are the most common mental illness in the US, affecting 18% of the population. Obsessive compulsive disorder (OCD), in particular, is one of the most disabling with a diminished quality of life. Only…
Mouse model of cholinergic dysfunction to evaluate cognitive enhancers for Alzheimer’s disease treatment
Value Proposition Defects in acetylcholine transmission have been associated with several major neurodegenerative disorders including Alzheimer’s disease, dementia, cerebral palsy, Parkinson’s disease, Huntington’s disease and myasthenia gravis. Although cholinergic dysfunction has been implicated in these…
A user-friendly web-based query tool for patient care data – Duke Enterprise Data Unified Content Explorer (DEDUCE)
Value Proposition In many healthcare organizations, comparative effectiveness research and quality improvement (QI) investigations are hampered by a lack of access to data created as a byproduct of patient care. Data collection often hinges upon…
Methods and devices for ultrasound scanning
In patients who are obese or exhibit signs of pulmonary disease, standard transthoracic scanning may yield poor quality cardiac images. For these conditions, two-dimensional transesophageal echocardiography (TEE) is established as an essential diagnostic tool. Current…
Improving the efficacy of anti-PD-1 antibody immunotherapy
Value Proposition Despite the significant impact that the checkpoint inhibitor immunotherapies have generated in clinical oncology, the majority of our cancer patients still do not benefit from this treatment modality. While the PD-1/PD-L1 system plays…
Rapid immunoassay to detect anti-EGFRviii levels to evaluate vaccine efficacy
Value Proposition Tumor-specific molecules offer the possibility of targeted cancer therapy using monoclonal antibodies (mAbs) specifically directed against the tumor-specific molecule. However, it has proven difficult to identify tumor-specific molecules. Overexpression of EGFR in human…
Drug diversion surveillance dashboard
Value Proposition Prescription drug diversion is defined as the illegal distribution or misuse of prescription medications. Drugs that are susceptible to abuse and addiction in at-risk individuals are commonly involved. In the light of nationwide…
Mining microbial genomes for biologically active compounds
Most microbes of importance to human and environmental health are not amenable to experimentation. As a result, we do not know what molecules these microbes use to manipulate their environment- many of which are likely…
A universal antidote for aptamer therapeutics
Value Proposition With an ever increasing number of people taking numerous medications, the need to safely administer drugs and limit unintended side effects has never been greater. Antidote control remains the most direct means to…
Gene therapy for Crb1 retinopathies
Value Proposition Current treatments for retinal disease include laser surgeries, injectable corticosteroids, and other medications which may slow the process of retinal degeneration but are not able to stop it. The Crb1 protein has been…