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Antibodies for the detection of Ebola virus infection
Value Proposition Ebola Virus Disease (EVD) is a severe, often fatal illness in humans caused by one of five different Ebola viruses. The virus is transmitted to people from wild animals and spreads in the…
Improving osteoarthritis treatment through facilitated transport of bisphosphonates to chondrocytes by vitamin C
Value Proposition Osteoarthritis is the most prevalent of all forms of arthritis and the second greatest cause of disability worldwide. The Centers for Disease Control and Prevention estimates that osteoarthritis affects over 30 million adults…
MEK inhibitors as therapeutic agents and diagnostic tools for hemoglobinopathies, including thalassemia
Value Proposition Patients with sickle cell disease experience acute vaso-occlusive “crises”, which lead to significant pain, multiple organ damage, and eventually organ failure. Such crises are caused largely by their abnormal sickle red blood cells,…
Improved hard-decision decoding for generalized product codes
Value Proposition When baseband signals are transmitted over communication channels, errors often arise due to noise in the channels. Forward error correction (FEC) is a method of obtaining error control in data transmission, for enhanced…
Biomarkers to measure patient platelet functional status on aspirin and predict cardiovascular events
Value Proposition Aspirin is the most commonly prescribed anti-platelet medication for prevention of acute coronary syndrome (ACS), which continues to be the leading cause of morbidity and mortality in the U.S. Aspirin has long been…
Diagnostic and treatment for chronic and acute phase myeloid leukemia
Value Proposition While cancer therapies have increased survival for many tumor types, the reality is that 50-60% of cancer patients will die from the disease. This highlights a need for the continued search for targeted…
Compact telescope design for light scanning systems
Value Proposition Scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) are retinal imaging modalities commonly utilized in the clinic to diagnose retinal diseases. SLO is a confocal imaging technique similar to confocal microscopy that…
Development of novel therapeutic splice-switching oligonucleotides against aggressive prostate cancer
Value Proposition One in twelve men will be diagnosed with prostate cancer in their lifetime. Castration resistant prostate cancer, which resists traditional hormone therapies and continues to grow and often metastasize with poor survival outcomes,…
SUMO as a marker of cancer development and target for cancer therapy
Value Proposition Cancer therapy remains challenging, and the production of new inhibitor therapies is stinted by the need for clear successful targets that will block tumor cell proliferation. Small ubiquitin-like modifier (SUMO) proteins and the…
Real-time wireless power transfer control for passive backscattering devices
A method and apparatus is disclosed herein for real-time wireless power transfer control. In one embodiment, a system comprises: an RF-energy harvesting sensor tag operable to generate a first backscatter signal and at least one…
GaN-based nitric oxide sensors and methods of making and using the same
Technology GaN-based heterojunction field effect transistor (HFET) sensors are provided with engineered, functional surfaces that act as pseudo-gates, modifying the drain current upon analyte capture. In some embodiments, devices for sensing nitric oxide (NO) species…
Cell line model of enzalutamide resistant prostate cancer
Traditionally, AR drug discovery has used both ligand and AR structure-based design, seeking antagonists by classical ligand binding assays or cellular reporter assays that assess functional antagonism of androgen-dependent transcriptional activation. While these largely empirical…