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Development of novel therapeutic splice-switching oligonucleotides against aggressive prostate cancer
Value Proposition One in twelve men will be diagnosed with prostate cancer in their lifetime. Castration resistant prostate cancer, which resists traditional hormone therapies and continues to grow and often metastasize with poor survival outcomes,…
SUMO as a marker of cancer development and target for cancer therapy
Value Proposition Cancer therapy remains challenging, and the production of new inhibitor therapies is stinted by the need for clear successful targets that will block tumor cell proliferation. Small ubiquitin-like modifier (SUMO) proteins and the…
Real-time wireless power transfer control for passive backscattering devices
A method and apparatus is disclosed herein for real-time wireless power transfer control. In one embodiment, a system comprises: an RF-energy harvesting sensor tag operable to generate a first backscatter signal and at least one…
GaN-based nitric oxide sensors and methods of making and using the same
Technology GaN-based heterojunction field effect transistor (HFET) sensors are provided with engineered, functional surfaces that act as pseudo-gates, modifying the drain current upon analyte capture. In some embodiments, devices for sensing nitric oxide (NO) species…
Cell line model of enzalutamide resistant prostate cancer
Traditionally, AR drug discovery has used both ligand and AR structure-based design, seeking antagonists by classical ligand binding assays or cellular reporter assays that assess functional antagonism of androgen-dependent transcriptional activation. While these largely empirical…
Cell line model of castration resistant prostate cancer
Traditionally, AR drug discovery has used both ligand and AR structure-based design, seeking antagonists by classical ligand binding assays or cellular reporter assays that assess functional antagonism of androgen-dependent transcriptional activation. While these largely empirical…
Methods of treatment in diseases treated with therapeutic proteins
The present invention relates, in general, to a method of treating patients undergoing enzyme replacement therapy (ERT) or other therapy involving the administration of a proteinaceous therapeutic agent as well gene replacement therapy with non-viral…
Selective inhibition of mammalian gene expression by endogenous production of designed micro RNAs (miRNAs)
This patent pending technology uses artificial miRNAs, transcribed from a plasmid or viral vector, to specifically and stably eliminate protein expression for individual gene targets both in vitro and in vivo. The unique temporal and/or…
Neural signal selection algorithm for a multichannel acquisition system
Technology Methods, systems, and computer program for brain machine interfaces which transmitts neural signal information. It provides a method for selectively enabling and disabling channels in order to improve efficiency in the transmission and processing…
Aptamers to VMF
Focused aptamer libraries are constructed in accordance with a proteome (i.e., complex mixture of native biomolecules). The libraries may be screened to identify one or more candidate aptamers with desired biological activities other than specific…
Mice carrying functional single nucleotide polymorphisms in brain-specific trytophan hydroxylase(Tph2)
We have developed mice expressing 2 different mutant alleles of the brain-specific tryptophan hydroxylase gene (Tph2). Tryptophan hydroxylase is the rate limiting enzyme involved in the synthesis of serotonin. These mice have significantly reduced levels…