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A method for end-to-end spatial accuracy quality assurance for radiosurgery
Unmet Need Radiation therapy is an essential element of cancer treatment that benefits 4 million diagnosed patients every year. The ability to deliver complex three-dimensional distributions of dose that conform to even irregularly shaped lesions…
A method for reducing speckle and improving resolution in ultrasound imaging
Value Proposition For many years, ultrasound imaging has been an important and popular medical imaging method. The speckle texture in ultrasound images limits the detectability of low contrast targets. With size on the order of…
Leukocyte phenotyping methods to provide prognostic information and risk/resilience stratification for surgical procedures and critical illness
Unmet Need It is estimated that surgical complications arise in 16.4%, or almost 1 in 6 surgical procedures in the United States. Most complications have an immunological basis related to infection or aberrant adaptation to…
Novel epigenetic therapy for Prader Willi Syndrome
Unmet Need Prader-Willi Syndrome (PWS) is a rare and complex genetic disorder affecting an estimated 1 in 10,000 to 30,000 infants. Primarily caused by a paternal chromosome 15q11-q13 deletion, PWS presents a myriad of physical,…
Connecting cardiac and respiratory 3DCT imaging for 5DCT heart motion management
Unmet Need Ventricular tachycardia (VT) is a primary condition of heart disease noted as an irregularity of heart rhythm due to improper electrical signaling in the ventricles that causes an abnormally high heart rate. VT…
A functionally selective ghrelin receptor (GHSR) ligand for treatment of chemical and food addiction
Unmet Need The number of Americans with addiction-related disorders, including substance use disorders (SUD) and food addiction is increasing rapidly each year. Recent estimates indicate that >20 million people in the U.S. have been diagnosed…
Methods and compositions to sense m6A RNA modifications using a genetically encoded sensor
Unmet Need Gene expression is highly regulated through the addition of chemical modifications to RNA molecules. One such modification is methylation of adenosine residues to form m6A, a modified nucleotide which is found in thousands…
Tools for the rational design of improved odorant ligands and receptors
Unmet Need Our sense of smell, or olfaction, is integral to myriad aspects of everyday life, from our health and safety to our personal preferences. Yet the mechanisms behind olfaction are not well understood, leading…
A method to increase the durability and lifespan of commercially available soft polymer networks
Unmet Need Soft polymers are used for a variety of products including biomedical implants, footwear, and tires. Having a more durable polymer product will increase not only the lifespan of the product but also the…
Bioresorbable lactone-based elastomers that can be used in continuous digital light processing 3D printing applications
Unmet Need The global market for 3D printing, or additive manufacturing, is growing rapidly with a compound annual growth rate of approximately 21% predicted to occur until 2027. Medical and dental products account for the…
Method for the in vitro differentiation of human dendritic cells from hematopoietic stem cells for research and immunotherapy development
Unmet Need Dendritic cells (DCs) play a critical role in the adaptive immune response by capturing and presenting antigens to activate cytotoxic T-cells. As such, naturally occurring DCs are thought to have crucial antitumor activity…
Structural variants of TERT in brain tumors
Unmet Need Glioblastoma is the most common type of malignant brain tumor, and accounts for 47.7% of all brain cancer cases. Despite aggressive treatment, the median overall survival for glioblastoma is 15 to 18 months.…