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Using oxidative cell death to target RB1-deficient prostate cancer

Using oxidative cell death to target RB1-deficient prostate cancer

Unmet Need In the first quarter of 2023, there were approximately 288,300 Americans diagnosed with prostate cancer, accounting for about 15% of all new cancer diagnoses. The five-year survival rate of patients with prostate cancer…

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Gene therapy for non-alcoholic steatohepatitis and associated liver fibrosis

Gene therapy for non-alcoholic steatohepatitis and associated liver fibrosis

Unmet Need Driven by the rising tide of obesity and lack of medical treatment, it is estimated that 1 out of 4 adults in the US has non-alcoholic fatty liver disease or non-alcoholic steatohepatitis (NAFLD/NASH).…

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Method for streamlining deep brain stimulation control parameters determination in Parkinson’s Disease

Method for streamlining deep brain stimulation control parameters determination in Parkinson’s Disease

Unmet Need Parkinson’s disease (PD) is estimated to impact 10 million people worldwide. Currently, there are no cures for the disease. While treatments have significantly improved symptoms in patients, side effects of the pharmaceutical treatments…

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Methods and formulation to improve cellular survival of thawing after cryopreservation

Methods and formulation to improve cellular survival of thawing after cryopreservation

Unmet Need Cryopreservation is the main method of long-term storage and transport of living cells, and it is used for cell lines and patient samples such as stem cells, CAR-T cells, bone marrow, cord blood,…

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A device for clinical wet-to-wet connections that alleviates healthcare provider anxiety and enhances patient quality of care

A device for clinical wet-to-wet connections that alleviates healthcare provider anxiety and enhances patient quality of care

Unmet Need Extracorporeal membrane oxygenation (ECMO) is a rapidly growing method of providing life-saving support to a patient suffering from heart or lung failure. Between 2010 and 2021 ECMO runs in the United States grew…

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Targetable plasmid removal method

Targetable plasmid removal method

Unmet Need Bacterial pathogens represent a major challenge in the healthcare system. Hospitals harbor complex microbial communities where different bacterial pathogens can transfer undesirable plasmids that encode virulence and antibiotic resistance. This results in more…

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Alzheimer’s Disease Risk Calculator

Alzheimer’s Disease Risk Calculator

Unmet Need About 10% of people above the age of 65 have Alzheimer’s disease (AD). AD varies significantly across patients, both in initial presentation and severity, as well as in the rate of disease progression.…

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A method for selectively blocking nerve fibers during neurostimulation treatment using kilohertz frequency electrical signals

A method for selectively blocking nerve fibers during neurostimulation treatment using kilohertz frequency electrical signals

Unmet Need In the past three decades implanted neurostimulation devices have become widely adopted driven largely by their ability to treat a range of clinical conditions with a “drug-free” solution. The $6.6 billion dollar market…

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All-in-one DNA polymerases for hot start PCR

All-in-one DNA polymerases for hot start PCR

Unmet Need Polymerase chain reaction (PCR) is among the most common reactions conducted in life sciences, medical, and clinical laboratories. This technique is used for numerous applications such as clinical diagnoses, biological technologies, molecular cloning,…

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A novel immune competence blood test to predict responsiveness of tumors to cancer immunotherapy

A novel immune competence blood test to predict responsiveness of tumors to cancer immunotherapy

Unmet Need Cancer immunotherapy provides great advantages over traditional cytotoxic chemotherapy and radiation with more durable clinical outcomes and an improved quality of life. The number of US patients eligible for immunotherapy was estimated to…

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A protein that promotes crop immunity without compromising growth

A protein that promotes crop immunity without compromising growth

Unmet Need The human population is growing, and more food will be needed to sustain the global community, with an expected increase in total global food demand of 35% to 56% in the next 25…

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Toolkit to edit any gene with universal CRISPR/Cas9 vectors

Toolkit to edit any gene with universal CRISPR/Cas9 vectors

Unmet Need Genetic editing with the CRISPR/Cas9 system has quickly become ubiquitous in biotechnology research. One common application is studying proteins by editing the genes that encode them. Proteins have numerous functions, acting as receptors,…

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