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An automated system for dermatological laser surgery

An automated system for dermatological laser surgery

Value Proposition Laser-based devices show promise for highly effective treatment of a range of cutaneous applications, including skin rejuvenation, tattoo removal, hair removal, vascular and pigmented lesions, and even skin cancers. During these procedures, a…

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Targeted delivery of gene therapy via exosomes for cardiomyocyte reprogramming

Targeted delivery of gene therapy via exosomes for cardiomyocyte reprogramming

Unmet Need Every year, close to 1 million Americans experience a heart attack. A heart attack results in the loss of specialized cells called cardiomyocytes, which are crucial for the heart’s contraction and rhythmic beating.…

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FK506/FK520 analogs modified to increase fungal specificity and reduce immunosuppression

FK506/FK520 analogs modified to increase fungal specificity and reduce immunosuppression

Unmet Need Fungal infections are becoming increasingly prevalent worldwide, with 150 million cases and 1.7 million fatalities reported in the last year alone. The challenge in treating these infections stems from the rise of multi-drug-resistant…

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Novel RNA-based anti-cancer therapeutic for sustained immunotherapy by combined pattern recognition receptor (PRR) activation and anti-microRNA therapy (AMT)

Novel RNA-based anti-cancer therapeutic for sustained immunotherapy by combined pattern recognition receptor (PRR) activation and anti-microRNA therapy (AMT)

Unmet Need Cancer is incredibly prevalent and current therapies are insufficient. Globally, lifetime prevalence is 1 in 5, and mortality is 1 in 9 in men and 1 in 12 in women. Solid tumors account…

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HIV treatment and prevention using broadly neutralizing antibodies

HIV treatment and prevention using broadly neutralizing antibodies

Unmet Need For over 40 years, the HIV pandemic has affected millions, reducing life expectancy and quality of life. As of 2021, 38.4 million people globally are living with HIV, with about 1.5 million new…

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Novel epigenome editors for multiplexed gene regulation

Novel epigenome editors for multiplexed gene regulation

Unmet Need Epigenome editors activate or inhibit gene expression without modifying the underlying DNA sequence. Consequently, these editors can reversibly fine-tune gene expression without the risk of permanently altering the genome or off-target editing. Epigenome…

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Splice switching oligonucleotides to restore PHKG2 expression in glycogen storage disease IX

Splice switching oligonucleotides to restore PHKG2 expression in glycogen storage disease IX

Unmet Need Glycogen Storage Disease IX (GSD IX) is a rare inherited disorder primarily caused by mutations in the PHKG2 gene, leading to significant deficiencies in glycogen metabolism. Patients typically present with a variety of…

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Methods of treatment in diseases treated with therapeutic proteins

Methods of treatment in diseases treated with therapeutic proteins

Unmet Need The challenge of antibody formation against protein replacement therapies (PRT) significantly impacts the efficacy of treatments as patients often develop anti-drug antibodies, particularly those who are CRIM-negative, leading to adverse outcomes and limiting…

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A fluorescent probe for monitoring beta-secretase activity in cells

A fluorescent probe for monitoring beta-secretase activity in cells

Unmet Need Alzheimer’s Disease (AD) is characterized by the accumulation of amyloid-beta (Aβ) plaques, which lead to neurotoxicity, synaptic damage, and neuronal cell death. Current therapeutic approaches face significant challenges due to the complex nature…

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Novel immune checkpoints for cancer immunotherapy with tumor infiltrating lymphocytes

Novel immune checkpoints for cancer immunotherapy with tumor infiltrating lymphocytes

Unmet Need Adoptive cell therapy (ACT), or cellular immunotherapy, uses immune cells to combat cancer. Since 2017, CAR-T therapies have been rapidly adopted for hematological malignancies. However, for treating solid tumors, which account for 90%…

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Toolkit to edit any gene with universal CRISPR/Cas9 vectors

Toolkit to edit any gene with universal CRISPR/Cas9 vectors

Unmet Need Genetic editing with the CRISPR/Cas9 system has quickly become ubiquitous in biotechnology research. One common application is studying proteins by editing the genes that encode them. Proteins have numerous functions, acting as receptors,…

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Novel Method for Creating and Modifying Stable Cell Lines for Enhanced Proteomic Analysis

Novel Method for Creating and Modifying Stable Cell Lines for Enhanced Proteomic Analysis

Unmet Need Characterizing the composition and function of protein complexes can facilitate the understanding of key cellular processes. Indeed, the global proteomics market was estimated to be USD 25.9 billion in 2021. However, the analysis…

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