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Clinically-Linked ECG and Arrhythmia Repository (CLEAR)

Clinically-Linked ECG and Arrhythmia Repository (CLEAR)

Invention Summary Duke inventors have developed a database of digital 12- lead ECG samples that represent key rhythms of cardiac disorders. Each patient’s disorder was validated by a licensed and board-certified cardiovascular medicine physician to…

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Bacterial voltage gated ion channels for cardiac reprogramming

Bacterial voltage gated ion channels for cardiac reprogramming

Unmet Need Untreated cardiovascular disease (CVD) can lead to irreversible heart damage. This occurs when ischemia — inadequate blood flow — leads to the death of heart muscle fibers that conduct electrical impulses. Consequently, scar…

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A spatial coherence filtering method to increase resolution in color-flow ultrasound imaging

A spatial coherence filtering method to increase resolution in color-flow ultrasound imaging

Unmet Need Color-flow ultrasound imaging is a technique that allows for visualization of blood flow within tissues and is frequently used to diagnose cardiovascular abnormalities, guide needle biopsies, examine tumor vascularity, and measure blood flow…

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Zwitterionic-coated surgical mesh to minimize intra-abdominal adhesions

Zwitterionic-coated surgical mesh to minimize intra-abdominal adhesions

Unmet Need Four million abdominal surgeries are performed annually in the United States. Abdominal adhesions, or fibrous bands that bind tissue together, represent a significant postoperative complication occurring in >50% of patients undergoing abdominal surgery.…

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Feature-free photogrammetric 3D imaging with cameras under unconstrained motion

Feature-free photogrammetric 3D imaging with cameras under unconstrained motion

Unmet Need With the increasing development of camera-based sensors for applications such as virtual and augmented reality, there is more demand for technologies that can image 3D structures and create interpretable digital representations – a…

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Duke Head and Neck Model

Duke Head and Neck Model

Neck injury remains a significant societal problem with large financial costs and personal suffering. The cervical spine is vulnerable to severe injury in settings ranging from automotive crashes to athletic accidents. While cadaveric studies conducted…

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A biodegradable fixation device for breast implants

A biodegradable fixation device for breast implants

Unmet Need Breast augmentation and reconstruction is the 5th leading cosmetic surgery procedure of the 1.5 million cosmetic procedures done in the United States in 2020. About 12% of these procedures result in the implants…

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POLARIS – a probabilistic soil classification and property database over the contiguous United States at a 30-meter spatial resolution

POLARIS – a probabilistic soil classification and property database over the contiguous United States at a 30-meter spatial resolution

Unmet Need The soil properties have a critical impact on the accuracy of the land surface and hydrologic models, which are essential for applications in monitoring the climate and optimizing agriculture. The soil monitoring market…

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Screening tools for separately measuring fear avoidance, negative pain coping, and negative mood in patients suffering from musculoskeletal pain

Screening tools for separately measuring fear avoidance, negative pain coping, and negative mood in patients suffering from musculoskeletal pain

Unmet Need Chronic musculoskeletal (MSK) pain affects approximately 1.75 billion people globally. Chronic MSK pain is especially common and costly, affecting 25% of the US population and 18% in Europe. If not adequately treated, patients…

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A longitudinal education database for insight into medical school outcomes

A longitudinal education database for insight into medical school outcomes

Unmet Need There are roughly 150,000 medical residents in the US, and each trainee must meet certain benchmarks as they progress through their training. Each resident will have many datapoints collected over the course of…

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Gene expression assay to determine radiation exposure

Gene expression assay to determine radiation exposure

Unmet Need Ionizing radiation poses a significant risk as an environmental hazard and is linked to the development of multiple cancers in adults and children. Healthcare professionals, nuclear power plant employees, and research scientists are…

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New small molecules targeting castration-resistant prostate cancer

New small molecules targeting castration-resistant prostate cancer

Unmet Need Prostate cancer (PC) is the second most common male cancer globally and represents 15% of all cancers diagnosed in males. An estimated 34,700 deaths were predicted to occur from PC in the U.S.…

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