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Coded aperture X-ray scatter imaging
Value Proposition The ability to non-invasively image the molecular composition of an object is desirable in a number of application areas such as medical imaging, security, structural integrity verification, and homeland defense. While x-ray imaging…
Structured illumination for compressive tomography
Value Proposition Tomographic imaging is a well-known imaging method where an object is interrogated by a set of illuminating rays that are transmitted through the object along a set of paths. Unfortunately, an inordinate number…
Sparse aperture time of flight imaging
Value Proposition Millimeter wave imaging system have been widely used for security applications such as detecting concealed weapons and obstruction under low visibility conditions. Many current airport scanners perform holographic reconstruction of the target, but…
Prochelators as targeted prodrugs for prostate cancer
Value Proposition Globally, prostate cancer is the second-leading cause of new cancer cases in men and the sixth-leading cause of cancer-related death in men. Prostate-related health issues are on the rise, and the number of…
Prognostic and predictive blood-based biomarkers for pancreatic cancer
Value Proposition Pancreatic cancer is among the deadliest types of cancer, with only 8.2% of patients surviving five years after diagnosis. Therapeutics that inhibit either VEGF signaling pathways or mitogenic signaling through the epidermal growth…
Nonlinear system model and method for computing and optimizing athletic performance and rehabilitation
Value Proposition Training is widely accepted as a method to improve one’s performance in sports. However, athletes typically have to rely on experience, heuristics, and rough approximations to design their training routines. Despite tremendous advances…
Increasing the half-life of therapeutic proteins and peptides using elastomeric-like polypeptides with environmental sensitivity
Value Proposition Since insulin was used as the first therapeutic protein in a clinical setting, the field of protein therapeutics has rapidly expanded. From 2014-2018, therapeutic proteins had the highest compound annual growth rate of…
Alteration of dendritic cell metabolism to augment cancer vaccine efficacy
Value Proposition Despite recent advances, many cancers remain refractory to available immunotherapeutic strategies. Immunotherapy is currently one of the treatment options for the 100,350 new melanomas that are estimated to be diagnosed in 2020 by…
Wireless RF receive/transmit coils for simultaneous MR image acquisition and data communication
Wireless communication between the MRI scanner and its subsystems (i.e. ~ RF coils, on-board sensors and monitors, local B0 shimming, active detuning, etc) is vital to the development of next generation MRI scanners. The removal…
MR method and apparatus for on-resonance magnetization transfer (MT) preparation using time delay-separated matched pairs of adiabatic pulses
Magnetic resonance imaging (MRI) systems and methods using adiabatic tip-down and matchedadiabatic flip-back pulses are disclosed. According to an aspect, a system includes a signal generator configured to generate a pulse sequence for on-resonance magnetization…
Long T1 artifact suppression technique for magnetic resonance imaging
A method of suppressing artifacts arising from tissue, fluids, or other long-T1 species when acquiring magnetic resonance data with a segmented pulse sequence that assumes that magnetization is at steady state, said method including suppressing…
CD47/SIRPα checkpoint blockade in combination with HER2 antibody for the treatment of HER2-positive breast cancer
Value Proposition Approximately 20% of breast cancers overexpress the human epidermal growth factor receptor type 2 (HER2), which is recognized as an oncogenic driver of an aggressive cancer phenotype with a poor prognosis. The clinical…