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Sensor system to accurately measure head dynamics and kinematics

Sensor system to accurately measure head dynamics and kinematics

Unmet Need It is estimated that over 1.2 million individuals working in the United States have vibration syndrome due to long-term exposure to tools or machinery. This can lead to blood vessel and nerve damage,…

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A highly sensitive next-generation sequencing technique for detecting cancerous mutations

A highly sensitive next-generation sequencing technique for detecting cancerous mutations

Unmet Need Next-generation sequencing (NGS) methods have been widely adopted for both biological discovery and diagnostics in cancer patient care. In particular, the identification of new mutations or groups thereof arising within oncogenic pathways across…

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A plate assay for in situ imaging of microbial growth in biofilms

A plate assay for in situ imaging of microbial growth in biofilms

Unmet Need As the study of antimicrobial-resistant biofilms becomes increasingly relevant, there is a need for a microplate assay that allows for continuous monitoring of biofilm formation by confocal laser scanning microscopy (CLSM). Microplate assays…

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An eLearning platform with comprehensive engagement analytics and curated content to advance surgical education

An eLearning platform with comprehensive engagement analytics and curated content to advance surgical education

Unmet Need As medicine continues to evolve and complexify while academic faculty face growing time constraints, self-study tools like online learning (eLearning) become invaluable for bridging the gap in medical trainee education. In particular, eLearning…

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The Delirium Care Process Model: An interactive flowchart to standardize and inform delirium diagnosis and care

The Delirium Care Process Model: An interactive flowchart to standardize and inform delirium diagnosis and care

Unmet Need In the United States, the geriatric population was estimated to be about 55.8 million in 2020, comprising 17% of the total population. The size of this population is only expected to increase as…

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The Fit Together Playbook: a curriculum that fosters community partnerships to fight child obesity

The Fit Together Playbook: a curriculum that fosters community partnerships to fight child obesity

Unmet Need Childhood obesity affects 1 in 5 children resulting in more than 14.7 million obese children ages 2-19 years old in the United States. Many factors can contribute and cause obesity including diet, lack…

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Branched-chain amino acid metabolism: novel targets and interaction pathways

Branched-chain amino acid metabolism: novel targets and interaction pathways

Unmet Need Branched chain amino acids (BCAA) leucine, isoleucine, and valine are essential for human health. However, BCAA are also known to be strongly elevated in the context of metabolic disease such as obesity, type…

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MEWS: a clinical model to predict probability of maternal sepsis trigger in obstetrics patients

MEWS: a clinical model to predict probability of maternal sepsis trigger in obstetrics patients

Unmet Need Sepsis is a life-threatening emergency characterized by an overactive and improper inflammatory response by the body to an infection or injury leading to tissue damage, organ failure and death if not treated promptly.…

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RXR modulators to improve the efficacy of immunomodulatory agents in multiple myeloma treatment

RXR modulators to improve the efficacy of immunomodulatory agents in multiple myeloma treatment

Unmet Need Multiple myeloma (MM) is the second most common hematological malignancy in the United States. Although current anti-myeloma therapeutics help patients live with the disease for more than 10 years, MM remains an incurable…

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Olfactory neuroblastoma mouse model

Olfactory neuroblastoma mouse model

Unmet Need Olfactory neuroblasoma (ONB) is an agressive tumor that is thought to arise in basal stem cells in the adult olfactory epithelium. This rare cancer affects 1 in 2.5 million people each year with…

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iPSC line to identify novel therapies for ARVC

iPSC line to identify novel therapies for ARVC

Technology Duke inventors have developed a novel induced pluripotent stem cell (iPSC) line that contains a mutation that impacts the TAX1BP3 gene, which causes arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC). Specifically, the iPSCs were derived from…

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Transgenic zebrafish to direct epicardial gene expression

Transgenic zebrafish to direct epicardial gene expression

Technology Duke inventors have generated a novel zebrafish model that allows researchers to study epicardial cells during embryonic heart development and myocardial regeneration. This zebrafish line is termed Tg(tcf21:CreER)pd42. Specifically, this transgenic model was created…

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