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HIV treatment and prevention using broadly neutralizing antibodies
Unmet Need For over 40 years, the HIV pandemic has affected millions, reducing life expectancy and quality of life. As of 2021, 38.4 million people globally are living with HIV, with about 1.5 million new…
Novel epigenome editors for multiplexed gene regulation
Unmet Need Epigenome editors activate or inhibit gene expression without modifying the underlying DNA sequence. Consequently, these editors can reversibly fine-tune gene expression without the risk of permanently altering the genome or off-target editing. Epigenome…
Splice switching oligonucleotides to restore PHKG2 expression in glycogen storage disease IX
Unmet Need Glycogen Storage Disease IX (GSD IX) is a rare inherited disorder primarily caused by mutations in the PHKG2 gene, leading to significant deficiencies in glycogen metabolism. Patients typically present with a variety of…
Methods of treatment in diseases treated with therapeutic proteins
Unmet Need The challenge of antibody formation against protein replacement therapies (PRT) significantly impacts the efficacy of treatments as patients often develop anti-drug antibodies, particularly those who are CRIM-negative, leading to adverse outcomes and limiting…
A fluorescent probe for monitoring beta-secretase activity in cells
Unmet Need Alzheimer’s Disease (AD) is characterized by the accumulation of amyloid-beta (Aβ) plaques, which lead to neurotoxicity, synaptic damage, and neuronal cell death. Current therapeutic approaches face significant challenges due to the complex nature…
Novel immune checkpoints for cancer immunotherapy with tumor infiltrating lymphocytes
Unmet Need Adoptive cell therapy (ACT), or cellular immunotherapy, uses immune cells to combat cancer. Since 2017, CAR-T therapies have been rapidly adopted for hematological malignancies. However, for treating solid tumors, which account for 90%…
Toolkit to edit any gene with universal CRISPR/Cas9 vectors
Unmet Need Genetic editing with the CRISPR/Cas9 system has quickly become ubiquitous in biotechnology research. One common application is studying proteins by editing the genes that encode them. Proteins have numerous functions, acting as receptors,…
Novel Method for Creating and Modifying Stable Cell Lines for Enhanced Proteomic Analysis
Unmet Need Characterizing the composition and function of protein complexes can facilitate the understanding of key cellular processes. Indeed, the global proteomics market was estimated to be USD 25.9 billion in 2021. However, the analysis…
Data collection system for surgical instrument localization
Unmet Need The operating room represents the largest cost and profit center for health systems across the United States. Despite its importance, very little data is gathered describing open surgery. Surgical technique is more of…
Swipe-to-Locate: Enhancing Real-World Object and Event Localization
Unmet need Conventional techniques for mapping the location of real-world objects or events are successful at identifying the location of static objects at a gross level. Mobile devices such as smartphones typically include GPS for…
Solvent Free Resorbable Resin for 3D Printing
Unmet Need Biologically resorbable resins have allowed for incredible advances in 3D printed implantable device technology. Bone implants, stents, drug delivery scaffolds, and many other lifesaving devices can be custom printed to meet a patient’s…
Dark-Blood Delayed-Enhancement MRI: Improved Tissue Contrast and Blood-Pool Signal Suppression
Unmet Need Delayed-enhancement MRI (DE-MRI) is the standard for imaging myocardial infarction (MI), providing high-resolution maps of infarcted and viable myocardium. However, DE-MRI often suffers from poor differentiation between infarcted myocardium and the bright left…