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Novel biomarkers to detect Venous Thrombosis without radiation exposure in elderly patients

Novel biomarkers to detect Venous Thrombosis without radiation exposure in elderly patients

Unmet Need Venous thrombosis/thromboembolism (VT/E), the formation of a blood clot in vein, can be a life-threatening condition with 600,000 incidences in the US per year and affecting an estimated 10 million people globally. VT/E…

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Duke Anesthesia Resistance Scale (DARS), a postoperative delirium risk calculator

Duke Anesthesia Resistance Scale (DARS), a postoperative delirium risk calculator

Unmet Need More than 70 million surgeries are performed on older adults annually worldwide. The combined burden of anesthesia, surgery, and postoperative hospitalization increase risk of developing postoperative delirium in aging patients. Delirium is associated with…

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Transformative Peer coaching & training for young adults with chronic illness

Transformative Peer coaching & training for young adults with chronic illness

Unmet Need An excellent alternative for the growing burden of chronic illness is patient-centered self-management. This method empowers patients to manage their condition actively, improving treatment outcomes and reducing the burden on healthcare providers. Self-management…

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Complete in vivo Protein Lipidation through Dynamic Metabolic Control of Acyl-CoA Biosynthesis

Complete in vivo Protein Lipidation through Dynamic Metabolic Control of Acyl-CoA Biosynthesis

Unmet Need Protein therapeutics and biologics are becoming more common in healthcare. However, these molecules often struggle to cross epithelial barriers or cause immune reactions, necessitating either injection or direct site administration to be effective.…

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Non-invasive method to predict rates of post-operative cognitive problems

Non-invasive method to predict rates of post-operative cognitive problems

Unmet Need Older adults are at a higher risk of cognitive dysfunction after surgery, with postoperative delirium (POD) being the most common disorder. POD is characterized by inattentiveness and is seen in 70-80% of intensive…

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Database of PET Images positive for Cardiac Sarcoidosis

Database of PET Images positive for Cardiac Sarcoidosis

Description The Clinical Database consists of PET scan images for 4 patients (FDG+Ammonia PET) only who have been identified as positive for cardiac sarcoidosis collected, annotated and compiled by DUKE and subject to Duke University…

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Biomarkers and novel targets for metabolic disease leveraging branched-chain amino acid metabolism

Biomarkers and novel targets for metabolic disease leveraging branched-chain amino acid metabolism

Unmet Need 1 in 3 adults in the United States have a form of metabolic dysregulation, including diabetes, insulin resistance, obesity, non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). While these metabolic diseases range…

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Modeling an extreme ultraviolet lithography mask by a deep fully convolutional network

Modeling an extreme ultraviolet lithography mask by a deep fully convolutional network

Unmet Need Extreme ultraviolet (EUV) lithography is a patterning method that is at the forefront of semiconductor fabrication technology. EUV lithography uses wavelengths of light that are as small as 13 nm to produce incredibly…

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Automated Method for De-Identifying Digital Imaging and Communications in Medicine Meta-Data and Burned-in Pixel Text

Automated Method for De-Identifying Digital Imaging and Communications in Medicine Meta-Data and Burned-in Pixel Text

Unmet Need Clinical data that is organized and contains detailed patient information is critical for effectively treating high volumes of patients. One such form of clinical data includes medical images like magnetic resonance imaging (MRI),…

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Type I CRISPR-Cascade: precise gene modulation platform for human cell applications

Type I CRISPR-Cascade: precise gene modulation platform for human cell applications

Unmet Need The gene editing sector has experienced a transformative surge in technological advancements with the emergence of CRISPR-Cas systems. These systems offer unprecedented capability to modify and modulate genetic sequences, proving instrumental from fundamental…

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A novel non-addictive method for treating neuropathic pain associated with cancer

A novel non-addictive method for treating neuropathic pain associated with cancer

Unmet Need In the US alone, close to 1.9 million new cases of cancer are diagnosed each year and 44.5% of these patients will experience chronic pain. This type of chronic pain, called neuropathic pain,…

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Rapid non-invasive optical assay system for intraoperative breast tumor margin assessment

Rapid non-invasive optical assay system for intraoperative breast tumor margin assessment

Unmet Need Breast cancer is the most common non-skin cancer in women in the United States, accounting for 1 in 3 of all new female cancers each year. Breast conserving surgery is a common treatment…

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