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Modeling an extreme ultraviolet lithography mask by a deep fully convolutional network

Modeling an extreme ultraviolet lithography mask by a deep fully convolutional network

Unmet Need Extreme ultraviolet (EUV) lithography is a patterning method that is at the forefront of semiconductor fabrication technology. EUV lithography uses wavelengths of light that are as small as 13 nm to produce incredibly…

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Type I CRISPR-Cascade: precise gene modulation platform for human cell applications

Type I CRISPR-Cascade: precise gene modulation platform for human cell applications

Unmet Need The gene editing sector has experienced a transformative surge in technological advancements with the emergence of CRISPR-Cas systems. These systems offer unprecedented capability to modify and modulate genetic sequences, proving instrumental from fundamental…

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A novel non-addictive method for treating neuropathic pain associated with cancer

A novel non-addictive method for treating neuropathic pain associated with cancer

Unmet Need In the US alone, close to 1.9 million new cases of cancer are diagnosed each year and 44.5% of these patients will experience chronic pain. This type of chronic pain, called neuropathic pain,…

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Rapid non-invasive optical assay system for intraoperative breast tumor margin assessment

Rapid non-invasive optical assay system for intraoperative breast tumor margin assessment

Unmet Need Breast cancer is the most common non-skin cancer in women in the United States, accounting for 1 in 3 of all new female cancers each year. Breast conserving surgery is a common treatment…

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Holistic streamlined surgery patient perioperative risk assessment tool

Holistic streamlined surgery patient perioperative risk assessment tool

Unmet Need Surgery poses major burdens for hospitals and patients. As of 2023, there are 6,129 hospitals in the United States performing a staggering 50 million surgeries each year. Despite the increased scrutiny on the…

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Biomarkers and novel targets for metabolic disease leveraging branched-chain amino acid metabolism

Biomarkers and novel targets for metabolic disease leveraging branched-chain amino acid metabolism

Unmet Need 1 in 3 adults in the United States have a form of metabolic dysregulation, including diabetes, insulin resistance, obesity, non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). While these metabolic diseases range…

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A quantitative tool for real-time monitoring of cells cultured in a hollow fiber bioreactor

A quantitative tool for real-time monitoring of cells cultured in a hollow fiber bioreactor

Unmet Need With the rise of cell therapies such as CAR-T cells for cancer and potentially autoimmune diseases, the methods of manufacturing cells in an efficient and safe manner are being studied and optimized constantly.…

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Clinically-Linked ECG and Arrhythmia Repository (CLEAR)

Clinically-Linked ECG and Arrhythmia Repository (CLEAR)

Invention Summary Duke inventors have developed a database of digital 12- lead ECG samples that represent key rhythms of cardiac disorders. Each patient’s disorder was validated by a licensed and board-certified cardiovascular medicine physician to…

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Bacterial voltage gated ion channels for cardiac reprogramming

Bacterial voltage gated ion channels for cardiac reprogramming

Unmet Need Untreated cardiovascular disease (CVD) can lead to irreversible heart damage. This occurs when ischemia — inadequate blood flow — leads to the death of heart muscle fibers that conduct electrical impulses. Consequently, scar…

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A spatial coherence filtering method to increase resolution in color-flow ultrasound imaging

A spatial coherence filtering method to increase resolution in color-flow ultrasound imaging

Unmet Need Color-flow ultrasound imaging is a technique that allows for visualization of blood flow within tissues and is frequently used to diagnose cardiovascular abnormalities, guide needle biopsies, examine tumor vascularity, and measure blood flow…

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Zwitterionic-coated surgical mesh to minimize intra-abdominal adhesions

Zwitterionic-coated surgical mesh to minimize intra-abdominal adhesions

Unmet Need Four million abdominal surgeries are performed annually in the United States. Abdominal adhesions, or fibrous bands that bind tissue together, represent a significant postoperative complication occurring in >50% of patients undergoing abdominal surgery.…

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Feature-free photogrammetric 3D imaging with cameras under unconstrained motion

Feature-free photogrammetric 3D imaging with cameras under unconstrained motion

Unmet Need With the increasing development of camera-based sensors for applications such as virtual and augmented reality, there is more demand for technologies that can image 3D structures and create interpretable digital representations – a…

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