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Signals for onset-free conduction block
Unmet Need Neuromodulation and neurostimulation devices are used to control the responses of the nervous system and alleviate disease. Delivering to a nerve an alternating current at a high frequency can produce a nerve block…
Systems and methods for efficient prediction and design of neural stimulation
Unmet Need Bioelectronic therapy is the ability to deliver various electrical impulses to patients through implanted medical devices. These devices can treat heart failure, epilepsy, and chronic pain among other ailments. Depending on the disease,…
Elastomer films with strain-induced color change to detect functional failures
Unmet Need Elastomers are polymer materials that can recover their original shape after being deformed. These materials, such as rubber or some plastics, are widely used in industrial and commercial applications in the automobile and…
TRPV4 ion channels as a target in systemic pruritic diseases
Unmet Need Pruritus, or an itching sensation, is one common symptom shared by hepatobiliary diseases, intrahepatic cholestasis of pregnancy (between 0.2% of 2% of all pregnancies) chronic kidney disease (55% prevalence globally), and pruritic psoriasis.…
Targeted delivery of gene therapy for cardiac reprogramming with enhanced efficacy
Unmet Need Cardiac injury results in irreversible and permanent loss of cardiomyocytes, leading to heart failure with ~40% mortality within 4 years from diagnosis. It has been shown that directly reprogramming scar fibroblasts into new…
Methods and compositions to sense m6A RNA modifications using a genetically encoded sensor
Unmet Need Gene expression is highly regulated through the addition of chemical modifications to RNA molecules. One such modification is methylation of adenosine residues to form m6A, a modified nucleotide which is found in thousands…
A microscopy method for acquiring polarization-sensitive phase information in 3D
Unmet Need The majority of biological research and clinical diagnostics has involved the use of optical imaging systems for transparent specimens that rely on scalar properties like phase contrast. These systems have proved useful for…
Schenk Composer: A framework for algorithmic music generation
Unmet Need As artificial intelligence (AI) and machine learning become more commonplace in modern society, there is increasing demand for these tools to be incorporated in creative applications that normally rely completely on human intuition.…
A steerable and adjustable shock wave generator for kidney stone treatment
Unmet Need Lithotripsy is a non-invasive procedure used to break down kidney stones too big to pass through the urethra. This relies on electromagnetic or electrohydraulic waves passed from a tabletop machine through a patient’s…
Ultra-wideband transparent conductive electrode for solar and radiation heat management
Unmet Need In the United States, 37% of electricity consumption is attributable to residential use with a sizeable portion of that electricity going towards heating and cooling applications (15% of national energy consumption goes towards…
Novel immune checkpoints for cancer immunotherapy with tumor infiltrating lymphocytes
Unmet Need Adoptive cell therapy (ACT), also known as cellular immunotherapy, leverages immune cells to fight cancer. Examples include chimeric antigen receptor T-cell (CAR-T) therapy, engineered T-cell receptor (TCR) therapy, and tumor-infiltrating lymphocyte (TIL) therapy.…
Anti-LYPD3 CAR T-cell therapy for the treatment of squamous cell carcinoma
Unmet Need Chimeric Antigen Receptor (CAR) T-cell therapy, a form of immunotherapy, has proven highly effective against blood cancers such as leukemias and lymphomas. This therapy uses T-cells that are genetically engineering ex vivo to…