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Increasing the half-life of therapeutic proteins and peptides using elastomeric-like polypeptides with environmental sensitivity
Value Proposition Since insulin was used as the first therapeutic protein in a clinical setting, the field of protein therapeutics has rapidly expanded. From 2014-2018, therapeutic proteins had the highest compound annual growth rate of…
Alteration of dendritic cell metabolism to augment cancer vaccine efficacy
Value Proposition Despite recent advances, many cancers remain refractory to available immunotherapeutic strategies. Immunotherapy is currently one of the treatment options for the 100,350 new melanomas that are estimated to be diagnosed in 2020 by…
Wireless RF receive/transmit coils for simultaneous MR image acquisition and data communication
Wireless communication between the MRI scanner and its subsystems (i.e. ~ RF coils, on-board sensors and monitors, local B0 shimming, active detuning, etc) is vital to the development of next generation MRI scanners. The removal…
MR method and apparatus for on-resonance magnetization transfer (MT) preparation using time delay-separated matched pairs of adiabatic pulses
Magnetic resonance imaging (MRI) systems and methods using adiabatic tip-down and matchedadiabatic flip-back pulses are disclosed. According to an aspect, a system includes a signal generator configured to generate a pulse sequence for on-resonance magnetization…
Long T1 artifact suppression technique for magnetic resonance imaging
A method of suppressing artifacts arising from tissue, fluids, or other long-T1 species when acquiring magnetic resonance data with a segmented pulse sequence that assumes that magnetization is at steady state, said method including suppressing…
CD47/SIRPα checkpoint blockade in combination with HER2 antibody for the treatment of HER2-positive breast cancer
Value Proposition Approximately 20% of breast cancers overexpress the human epidermal growth factor receptor type 2 (HER2), which is recognized as an oncogenic driver of an aggressive cancer phenotype with a poor prognosis. The clinical…
UV sterilization of surgical drains
Value Proposition Surgical site infection (SSI) can result in increased readmission rates, longer hospital stays, increased admission to the ICU, increased antibiotic use, delayed wound healing, long term complications at the site, and death. Despite…
Lipidomics approaches for discovering biomarkers, therapeutic targets and improved therapies for the treatment of schizophrenia
This invention has utilized the power of lipidomics to profile lipid metabolites and to characterize changes in lipid metabolism as they relate to CNS disorders. Lipidomic signatures can guide the development of diagnostic, prognostic and…
Automatic inversion time adjustment method and apparatus using single-line acquisition for T1 assessment combined with automatic compartment detection and compartmental inversion time derivation for inversion-recovery magnetic resonance imaging
The field of the invention is Magnetic Resonance Imaging (MRI). The invention greatly simplifies the operation of an MRI scanner by automatically setting the timing parameter 'inversion time' (TI), which currently needs to be manually…
Methods for ablating niche cells in testis
Value Proposition Infertility affects 10-15% of couples and up to 50% of these cases are due to the male partner. While the largest proportion (30%) of these cases are idiopathic with no known causes and…
A smart fiber optic sensor system for quantitative tissue optical spectroscopy
Smart fiber optic sensors, systems, and methods for performing quantitative optical spectroscopy are disclosed. In one embodiment, smart fiber optic sensor can include a sensing channel, a calibration channel, and a pressure sensing channel. External…
Magnetic resonance imaging method for detecting magnetic field oscillations
This invention is a new magnetic resonance imaging method that can detect magnetic field oscillations in specific frequency bands, in particular those induced by neuroelectric activity in the brain. In contrast to existing neuroimaging techniques,…