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An induced pluripotent stem cell model of Duchenne muscular dystrophy
Unmet Need Duchenne muscular dystrophy (DMD) is a rare genetic disease that causes the skeletal and heart muscles to weaken. Due to a mutation in dystrophin, an important protein involved in muscle structure, individuals with…
Human cell line lacking both Dicer and PKR
Technology Duke inventors have created a human cell line that lacks functional dcr and pkr genes. Specifically, the HEK293T cells, a human cell line with a mutated dcr gene was modified using the CRISPR/Cas9 system…
Transgenic mouse strains to investigate biased ghrelin receptor (GHSR1a) drug candidates
Technology Duke inventors have created five novel transgenic mice with point, knockout, or humanizing mutations to the ghrelin receptor (GHSR1a): G protein-biased GHSR1a mouse (GHSR-P147A): CRISPR-Cas9 RNA-induced homology-directed repair (HDR) was used to create a…
VMAT2 heterozygous mouse line as a model of brain dysfunction associated with behavioral deficits
Technology Duke inventors have developed a novel mouse model that is heterozygous for vesicular monoamine transport 2 (VMAT2), a protein located in the central nervous system that transports monoamines such as dopamine and serotonin from…
Long extra-corporeal arterial sheaths and catheters for coronary angiography and intervention
Value Proposition Percutaneous coronary interventions (PCI) such as angioplasty and angiography can be performed for therapeutic as well as diagnostic reasons. Over 20 million angiography and 10 million angioplasty procedures are projected to be performed…
Pancreatic cancer treatment that inhibits the Piezo1/TRPV4 axis
Unmet Need Pancreatic cancer has one of the highest mortality rates of all cancer types in the US. The American Cancer Society predicts that about 64,000 people will be diagnosed with pancreatic cancer and 55,000…
A drug-infused hydrogel implant for glaucoma drainage devices
Unmet Need Glaucoma is an ocular disease involving heightened eye pressure most commonly leading to blindness, affecting roughly 3 million Americans. Current treatments include anti-steroidal or anti-inflammatory drugs to remove excess ocular fluid or decrease…
Wearable smart radiation reporting material
Unmet Need Excess radiation exposure can result in DNA damage and tissue injury. Individuals who are occupationally exposed to ionizing radiation need to monitor and track radiation exposures. Small, personal radiation dosimeters currently exist, but…
T-cell releasing antibody for breast cancer tumor metastasis prevention
Unmet Need Metastatic breast cancer is a deadly form of breast cancer with only 1/3 of patients diagnosed with it living to 5 years post-diagnosis. Metastasis can occur either at disease onset (6% of patients)…
Small molecule inhibitors of eHSP90 to treat autoimmune diseases
Unmet Need It is estimated that autoimmune diseases affect 1 out of every 10 individuals. These debilitating diseases are the result of the immune system inappropriately targeting and attacking the body. The resulting disease is…
Collection of novel CRISPR guide RNAs and their creation method
Unmet Need The advent of CRISPR-Cas9 technology has enabled targeted rapid modification of genes and sparked a biotechnology revolution. The CRISPR-Cas9 complex is composed of two parts: a guide RNA specific to the DNA sequence…
Method to express olfactory receptors for ultra-high sensitivity detection of odorants and other volatile chemicals
Unmet Need Artificial sensors for sight and sound are so ubiquitous that we frequently take them for granted. Whenever we ask Siri, join a conference call, or walk through an automatic door we benefit from…