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Plasmids with RNA aptamers to B-arrestin
Technology Duke inventors have created 10 novel plasmids which can be used for the production of RNA aptamers to β-arrestins through in vitro translation: pCR-TOPO-8R1-36 pCR-TOPO-8R2-1 pCR-TOPO-8R2-15 pCR-TOPO-8R2-16 pCR-TOPO-8R2-20 pCR-TOPO-8R2-21 pCR-TOPO-8R2-24 pCR-TOPO-11R2-5 pCR-TOPO-11R2-7 pCR-TOPO-11R2-15
Plasmids for the expression of B-arrestins and GRKs
Technology Duke inventors have generated 12 novel plasmids that can be used for the expression of β-arrestins and GRKs: pCDNA3-βarrestin1-Flag pCDNA3-βarrestin2-Flag pGEX-5G/LIC-βarrestin1 pGEX-5G/LIC-βarrestin2 pGEX-4T1-βarrestin1 C-terminus pGEX-4T1-βarrestin2 C-terminus pRK5-bGRK2 pRK5-bGRK3 pRK5-bGRK4 pRK5-hGRK5 pRK5-hGRK6 pRK5-hGRK26caax
B-arrestin biosensor cell lines
Technology Duke inventors have created 14 novel biosensor cell lines that can be used for the detection of translocation events, generation of signaling messages, and protein-protein interactions within cells: U2OS-βarrestin2-YFP U2OS-βarrestin1-YFP 293-βarrestin2-YFP 293-βarrestin1-YFP NIH-3T3-Smo-GFP HEK293-rATlaR-CFP,…
B-arrestin 1 and 2 conditional knockout mouse models
Technology Duke inventors have created two novel mouse lines for the acute ablation of β-arrestin 1 or β-arrestin 2: Conditional Flox/Cre (tet inducible) β-arrestin 1 KO mice (C57/BL6J background) Conditional Flox/Cre (tet inducible) β-arrestin 2…
Cell lines for the overexpression of GPCRs
Technology Duke inventors have generated five novel cell lines that can be used for the stable overexpression of several GPCRs: HEK293-rATlaR (2pM/mg) HEK293-rATlaR (600fM/mg) NIH-3T3-Flag-Smo 1.1 NIH-3T3-Flag-Smo 1.7 HEK293-Flag-β2AR (2pM/mg, W9)
Plasmids for the overexpression of GPCRs
Technology Duke inventors have generated four novel GPCR plasmids that can be used for the stable overexpression of several GPCRs: pcDNA3-Flag-β2AR pcDNA3-hAT1R (human) pcDNA3-HA-rATlaR (rat) pcDNA3-Flag-rATlaR (rat)
Functional Test Generation for AI Accelerators using Bayesian Optimization
Unmet Need Commercial use of artificial intelligence (AI) accelerator technology has grown rapidly as major advances are made in the field. However, when AI accelerators run into process-halting faults, substantial computational effort and time is…
Rat a1A-adrenergic receptor HeLa cell line
Technology Duke inventors have generated a human epithelial carcinoma (HeLa) cell line expressing the hamster α1B-adrenergic receptor.
Conditional microRNA-9 inhibitor and reporter mouse
Technology Duke inventors have created a novel mouse model termed the conditional microRNA-9 inhibitor and reporter mouse that shows the level of microRNA-9 in all tissues and demonstrates a microRNA-9 deficiency phenoptype. When bred with…
LpxH targeting antibiotics for Gram-negative bacteria
Unmet Need Antimicrobial resistance of bacteria to antibiotics is a major threat to public health. In 2019, 4.95 million deaths, 64% of all bacterial infection related deaths globally, were attributed to antimicrobial resistance to antibiotics.…
Hamster a1B-adrenergic receptor HeLa cell line
Technology Duke inventors have generated a human epithelial carcinoma (HeLa) cell line expressing the hamster α1B-adrenergic receptor.
ZIP fish: zebrafish insulin promoter
Duke scientists have created stable transgenic zebrafish with strict pancreatic, beta cell-specific expression of GFP in embryos, larvae and adult. This model can serve as a high throughput screen for diabetic drugs.