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A microscopy method for acquiring polarization-sensitive phase information in 3D
Unmet Need The majority of biological research and clinical diagnostics has involved the use of optical imaging systems for transparent specimens that rely on scalar properties like phase contrast. These systems have proved useful for…
Schenk Composer: A framework for algorithmic music generation
Unmet Need As artificial intelligence (AI) and machine learning become more commonplace in modern society, there is increasing demand for these tools to be incorporated in creative applications that normally rely completely on human intuition.…
A steerable and adjustable shock wave generator for kidney stone treatment
Unmet Need Lithotripsy is a non-invasive procedure used to break down kidney stones too big to pass through the urethra. This relies on electromagnetic or electrohydraulic waves passed from a tabletop machine through a patient’s…
Ultra-wideband transparent conductive electrode for solar and radiation heat management
Unmet Need In the United States, 37% of electricity consumption is attributable to residential use with a sizeable portion of that electricity going towards heating and cooling applications (15% of national energy consumption goes towards…
Novel immune checkpoints for cancer immunotherapy with tumor infiltrating lymphocytes
Unmet Need Adoptive cell therapy (ACT), also known as cellular immunotherapy, leverages immune cells to fight cancer. Examples include chimeric antigen receptor T-cell (CAR-T) therapy, engineered T-cell receptor (TCR) therapy, and tumor-infiltrating lymphocyte (TIL) therapy.…
Anti-LYPD3 CAR T-cell therapy for the treatment of squamous cell carcinoma
Unmet Need Chimeric Antigen Receptor (CAR) T-cell therapy, a form of immunotherapy, has proven highly effective against blood cancers such as leukemias and lymphomas. This therapy uses T-cells that are genetically engineering ex vivo to…
Adoptive T-cell immunotherapy to treat cancer caused by Epstein-Barr virus
Unmet Need Epstein-Barr virus (EBV) is an infectious disease that has been shown to cause a number of cancers originating from EBV-afflicted cells. Across the globe, EBV is associated with approximately 200,000 cases of malignancies…
EEG-based monitoring of brain recovery following stroke
Unmet Need Stroke is the third leading cause of disability in the US, affecting 800,000 annually. Stroke occurs when blood supply to the brain is impeded, leading to brain damage. Currently, recovery from stroke is…
Therapy for neurotensin positive cancers
Unmet Need Under normal conditions, neurotensin signaling is largely constrained to the nervous system. However, abnormal expression is seen in cancers that are aggressive or have a poor prognosis such as pancreatic, which has a12.5%…
Targeted delivery of gene therapy for cardiac injury treatment
Unmet Need After experiencing a heart attack, the adult human heart has no capacity to regenerate lost or damaged cardiac myocytes. This results in severely reduced heart function and eventually heart failure. There are more…
Extracellular vesicle biomarkers for detecting severity and progression of knee osteoarthritis
Unmet Need Osteoarthritis (OA) is a chronic degenerative joint disease that can impact the hands, knees, neck, lower back, and hips, leading to pain and restrictive mobility from the breakdown of connective tissue in these…
A computer vision approach for molecular subtyping of breast cancer using MRI
Unmet Need Breast cancer is the second leading cause of cancer-related deaths in American women and the fourth most common cause of all cancer-related deaths in the U.S. While early screening for cancer using magnetic…