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POLARIS – a probabilistic soil classification and property database over the contiguous United States at a 30-meter spatial resolution
Unmet Need The soil properties have a critical impact on the accuracy of the land surface and hydrologic models, which are essential for applications in monitoring the climate and optimizing agriculture. The soil monitoring market…
Screening tools for separately measuring fear avoidance, negative pain coping, and negative mood in patients suffering from musculoskeletal pain
Unmet Need Chronic musculoskeletal (MSK) pain affects approximately 1.75 billion people globally. Chronic MSK pain is especially common and costly, affecting 25% of the US population and 18% in Europe. If not adequately treated, patients…
A longitudinal education database for insight into medical school outcomes
Unmet Need There are roughly 150,000 medical residents in the US, and each trainee must meet certain benchmarks as they progress through their training. Each resident will have many datapoints collected over the course of…
Gene expression assay to determine radiation exposure
Unmet Need Ionizing radiation poses a significant risk as an environmental hazard and is linked to the development of multiple cancers in adults and children. Healthcare professionals, nuclear power plant employees, and research scientists are…
New small molecules targeting castration-resistant prostate cancer
Unmet Need Prostate cancer (PC) is the second most common male cancer globally and represents 15% of all cancers diagnosed in males. An estimated 34,700 deaths were predicted to occur from PC in the U.S.…
Optically transparent model kidney for surgical simulation
Unmet Need Surgical simulation is an important step in medical training. It is particularly critical for training in the urological field, which had 144 residency programs in 2023. Lithotripsy, a surgical procedure to treat kidney…
Improved beta oscillation burst detection for assessment of Parkinson’s disease
Unmet Need Parkinson’s disease is a debilitating ailment, though therapies such as deep brain stimulation via electrodes can improve symptoms. Such therapies rely on feedback from biomarkers to adjust the stimulation parameters. Such biomarkers may…
Type I CRISPR-Cas expands the human genome engineering toolkit
Unmet Need Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Associated Systems (Cas) provide immune protection to bacteria and archaea. CRISPR-Cas systems can be mono-subunit (Class 2) or multi-subunit (Class 1). Class 2 CRISPR-Cas systems, especially Type…
Pulsating ventilation through a single port
Unmet Need Ventilation is a necessity in any enclosed space that requires high air quality and sufficient air flow. Whether for larger spaces, such as buildings, or smaller spaces, such as airplanes, air ventilation provides…
A novel method to increase plant stress-resistance and yield
Unmet Need In 2023, as many as 333 million people were estimated to be acutely food insecure in the 78 countries with World Food Programme operations, more than doubling pre-pandemic levels. A major cause of…
Perfusate for optimized gene delivery to donor organs undergoing ex vivo machine perfusion
Unmet Need Effective gene delivery is notoriously difficult to achieve to an entire target organ. Gene therapies have traditionally been administered intravascularly, requiring high vector doses to attain therapeutic levels of expression. Because of this…
Revolutionary inhibitor target for enhanced immune response against breast cancer relapse
Unmet Need In the US, it is estimated that 1 in 8 women will develop breast cancer, of which 78% are estrogen receptor-positive (ER+) cases. These ER+ breast cancers are known for their risk of…