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A fluorescent probe for monitoring beta-secretase activity in cells
Molecular probes are provided for use in fluorescence microscopy procedures for monitoring beta-secretase enzyme (BACE) activity in living cells and organisms. The probes may be useful for monitoring Alzheimer's Disease-associated BACE in living cells. By…
A software for more easily monitoring physiological data through improved visualization and machine learning analysis
Value Proposition With inexpensive wearable sensors, physiological data monitoring has extended beyond clinical anesthesia and emergency medicine and into in-home healthcare. Waveforms such as electrocardiography (ECG) and photoplethysmography (PPG) contain valuable information about a patient’s…
Antimicrobial prochelators to target drug-resistant bacteria
Value Proposition According to the CDC, each year 2.8 million people in the United States develop an antibiotic-resistant infection, leading to more than 35,000 deaths. Beta lactams were the largest segment in the antibiotics market…
Patient-centric mobile data-architecture for electronic health records
Value Proposition Most Electronic Health Records (EHR) solutions available today are centered around the needs of healthcare providers, in that they allow providers to manage records of their patients. Moreover, they rely on centralized data…
Pharmacometabolomic for drug response phenotypes in the study of cardiovascular disease and its treatment
The present invention concerns the application of lipidomics to statin treatment for disorders such as cardiovascular disorders. Hence, the invention provides, among other things, a method of correlating a lipid profile with a positive or…
Dopamine transporter knockout mouse
We have developed knockout mice lacking the dopamine transporter. These mice are hyperactive, and display cognitive abnormalities consistent with enhanced dopaminergic neurotransmission. They have a heightened dopaminergic state (increase dopamine activity), mimicking certain behaviors associated…
Targeting novel cytokine receptors for anti-cancer activity on human cancers
Researchers at Duke University have discovered novel mRNA isoforms of a cytokine receptor that are expressed in a variety of cancers, including breast and cervical cancer cells. They have created cell lines expressing these abnormal…
Miniaturized, ultra-high density, multichannel electrode array for long-term, intra-cranial neuronal recordings
Technology A high-density multichannel microwire electrode array is disclosed. The array can comprise a variable number of electrodes. A method of assembling the array is further disclosed. Additionally, a plurality of devices employing the array…
Pulse duration and the dynamics of infrared tissue ablation
Value Proposition Laser-based ablation procedures are being investigated as a minimally invasive form of surgery to treat several forms of cancerous as well as non-cancerous lesions in neuro-, ophthalmic-, and cardiothoracic-surgery. While several different types…
Two dimensional electrophoresis cassette
A device for two-dimensional electrophoresis includes a cassette comprising two opposing plates. The two opposing plates form a first elongated portion for receiving a first elongated electrophoretic separation medium and a second portion extending away…
A diagnostic test for differentiating follicular thyroid adenoma for follicular thyroid carcinoma
Duke University is seeking a company interested in commercializing a novel method to distinguish follicular thyroid adenoma (FTA) from follicular thyroid carcinoma (FTC). Global estimates of thyroid cancer incidence for 2006 indicate half a million…
A gene implicated in the causation of kidney disease
Duke University is seeking a company interested in commercializing a risk assessment test and/or a therapeutic product targeting a gene which has been implicated in Glomerulonephritis. Focal and segmental glomeruloschlerosis (FSGS) is a significant cause…