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Dopamine transporter knockout mouse
We have developed knockout mice lacking the dopamine transporter. These mice are hyperactive, and display cognitive abnormalities consistent with enhanced dopaminergic neurotransmission. They have a heightened dopaminergic state (increase dopamine activity), mimicking certain behaviors associated…
Targeting novel cytokine receptors for anti-cancer activity on human cancers
Researchers at Duke University have discovered novel mRNA isoforms of a cytokine receptor that are expressed in a variety of cancers, including breast and cervical cancer cells. They have created cell lines expressing these abnormal…
Miniaturized, ultra-high density, multichannel electrode array for long-term, intra-cranial neuronal recordings
Technology A high-density multichannel microwire electrode array is disclosed. The array can comprise a variable number of electrodes. A method of assembling the array is further disclosed. Additionally, a plurality of devices employing the array…
Pulse duration and the dynamics of infrared tissue ablation
Value Proposition Laser-based ablation procedures are being investigated as a minimally invasive form of surgery to treat several forms of cancerous as well as non-cancerous lesions in neuro-, ophthalmic-, and cardiothoracic-surgery. While several different types…
Two dimensional electrophoresis cassette
A device for two-dimensional electrophoresis includes a cassette comprising two opposing plates. The two opposing plates form a first elongated portion for receiving a first elongated electrophoretic separation medium and a second portion extending away…
A diagnostic test for differentiating follicular thyroid adenoma for follicular thyroid carcinoma
Duke University is seeking a company interested in commercializing a novel method to distinguish follicular thyroid adenoma (FTA) from follicular thyroid carcinoma (FTC). Global estimates of thyroid cancer incidence for 2006 indicate half a million…
A gene implicated in the causation of kidney disease
Duke University is seeking a company interested in commercializing a risk assessment test and/or a therapeutic product targeting a gene which has been implicated in Glomerulonephritis. Focal and segmental glomeruloschlerosis (FSGS) is a significant cause…
Spike detection and data compression for a brain machine interface
Technology Systems, Methods, and Computer Program Products for Transmitting Neural Signal Information. Systems, method, and computer program products are provided for neural signal transmission. A system according to one embodiment can include a signal receiver…
APOE polymorphisms associated with SEPSIS risk
Duke University is seeking a company interested in commercializing a novel and versatile diagnostic/prognostic methodology which teaches identifying a patient who will have a post operative reduced risk of sepsis based on the pre-op detection…
Stem cell-derived factors for treating pathologic conditions
1.3 million Americans experience a heart attack (acute myocardial infarction or AMI) each year. A significant percentage of these patients die from restricted blood flow to the heart (ischemia) and significant loss of cardiac function.…
BANJO: Software and algorithms for the efficient and flexible inference of Bayesian and dynamic Bayesian networks
Duke University is seeking a company interested in commercializing a novel and versatile software. BANJO is software for the efficient and flexible inference of Bayesian and dynamic Bayesian networks. The target of the Banjo tool…
Optical assay system for intra operative assessment of tumor margins
Researchers at Duke University have developed a new optical device that differentiates cancer from normal tissues by measuring tissue composition, and meets the intraoperative performance requirement that surgeons demand. The surgeon surveys the tumor surface…