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3D cavitation mapping to improve laser lithotripsy for the treatment of kidney stones
Unmet Need The prevalence of kidney stones is on the rise, having increased from approximately 4% in the 1970s to nearly 10% today. Approximately 1 in 10 of Americans will experience a kidney stone in…
Gene therapy for ATP1A3-Related Neurologic Disorders
Unmet Need Alternating Hemiplegia of Childhood (AHC) is a rare neurologic disorder affecting children, causing episodes of temporary paralysis, dystonia, and severe behavioral issues, with prevalence estimates ranging from 1 in 1 million to 1…
Next-Generation Protein Linkers: Enhancing Stability and Targeting in Bioengineered Therapeutics
Unmet Need In protein bioengineering, stable and effective fusion proteins are crucial for therapeutic and diagnostic applications. However, current protein linkers often fail to maintain the stability, bioactivity, and targeted functionality needed, leading to limitations…
Portable mass spectrometer with high sensitivity and resolution
Unmet Need Mass spectrometry is a method of particle composition analysis. Traditionally, mass spectrometers are large devices with high energy requirements, restricting them to high-resource laboratory settings. Mass spectrometry can be used for isotopic analysis…
Revolutionizing material analysis with 5x faster broadband optimized time-temperature superposition (BOTTS) for rapid viscoelastic property insights
Unmet Need The Materials Genome Initiative Strategic Plan was adopted by the US in 2021 for the purposes of increasing knowledge on material structure property relationships to accelerate material development and innovation. This plan necessitates…
Method to produce durable synthetic rubbers that exhibit strain-induced crystallization (SIC) at ambient temperature
Unmet Need Polybutadiene is a synthetic rubber with high elasticity, resistance to wear, and robust ability to return to its original shape following deformation. These desirable characteristics have led to widespread use within manufacturing, namely…
Precision Gene Therapy for Parkinson’s Disease: Targeted SNCA Down-regulation in Dopaminergic Neurons
Unmet Need Parkinson’s disease (PD) is the second most common neurodegenerative disorder, affecting approximately 10 million people globally and 1 million in the U.S. PD is characterized by involuntary movements such as tremors, stiffness, and…
Feature-free photogrammetric 3D imaging with cameras under unconstrained motion
Unmet Need With the increasing development of camera-based sensors for applications such as virtual and augmented reality, there is more demand for technologies that can image 3D structures and create interpretable digital representations – a…
Acoustofluidic technologies for precision control in microfluidic systems
Unmet Need Achieving precise manipulation of particles, cells, and droplets in microscale liquid systems is a major challenge in life sciences, material sciences, and chemistry. Traditional microfluidic systems, which use hydrophobic channels and pressure differentials…
Mask embedding for realistic high-resolution image synthesis
Unmet Need General adversarial networks (GANs) are machine learning networks made of two neural networks competing with each other. They are used in medical imaging to generate training datasets for various medical imaging diagnostic processing…
An automated system for dermatological laser surgery
Value Proposition Laser-based devices show promise for highly effective treatment of a range of cutaneous applications, including skin rejuvenation, tattoo removal, hair removal, vascular and pigmented lesions, and even skin cancers. During these procedures, a…
Targeted delivery of gene therapy via exosomes for cardiomyocyte reprogramming
Unmet Need Every year, close to 1 million Americans experience a heart attack. A heart attack results in the loss of specialized cells called cardiomyocytes, which are crucial for the heart’s contraction and rhythmic beating.…