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Improved beta oscillation burst detection for assessment of Parkinson’s disease
Unmet Need Parkinson’s disease is a debilitating ailment, though therapies such as deep brain stimulation via electrodes can improve symptoms. Such therapies rely on feedback from biomarkers to adjust the stimulation parameters. Such biomarkers may…
Type I CRISPR-Cas expands the human genome engineering toolkit
Unmet Need Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Associated Systems (Cas) provide immune protection to bacteria and archaea. CRISPR-Cas systems can be mono-subunit (Class 2) or multi-subunit (Class 1). Class 2 CRISPR-Cas systems, especially Type…
Pulsating ventilation through a single port
Unmet Need Ventilation is a necessity in any enclosed space that requires high air quality and sufficient air flow. Whether for larger spaces, such as buildings, or smaller spaces, such as airplanes, air ventilation provides…
A novel method to increase plant stress-resistance and yield
Unmet Need In 2023, as many as 333 million people were estimated to be acutely food insecure in the 78 countries with World Food Programme operations, more than doubling pre-pandemic levels. A major cause of…
Perfusate for optimized gene delivery to donor organs undergoing ex vivo machine perfusion
Unmet Need Effective gene delivery is notoriously difficult to achieve to an entire target organ. Gene therapies have traditionally been administered intravascularly, requiring high vector doses to attain therapeutic levels of expression. Because of this…
Revolutionary inhibitor target for enhanced immune response against breast cancer relapse
Unmet Need In the US, it is estimated that 1 in 8 women will develop breast cancer, of which 78% are estrogen receptor-positive (ER+) cases. These ER+ breast cancers are known for their risk of…
Signals for onset-free conduction block
Unmet Need Neuromodulation and neurostimulation devices are used to control the responses of the nervous system and alleviate disease. Delivering to a nerve an alternating current at a high frequency can produce a nerve block…
Systems and methods for efficient prediction and design of neural stimulation
Unmet Need Bioelectronic therapy is the ability to deliver various electrical impulses to patients through implanted medical devices. These devices can treat heart failure, epilepsy, and chronic pain among other ailments. Depending on the disease,…
Elastomer films with strain-induced color change to detect functional failures
Unmet Need Elastomers are polymer materials that can recover their original shape after being deformed. These materials, such as rubber or some plastics, are widely used in industrial and commercial applications in the automobile and…
TRPV4 ion channels as a target in systemic pruritic diseases
Unmet Need Pruritus, or an itching sensation, is one common symptom shared by hepatobiliary diseases, intrahepatic cholestasis of pregnancy (between 0.2% of 2% of all pregnancies) chronic kidney disease (55% prevalence globally), and pruritic psoriasis.…
Targeted delivery of gene therapy for cardiac reprogramming with enhanced efficacy
Unmet Need Cardiac injury results in irreversible and permanent loss of cardiomyocytes, leading to heart failure with ~40% mortality within 4 years from diagnosis. It has been shown that directly reprogramming scar fibroblasts into new…
Methods and compositions to sense m6A RNA modifications using a genetically encoded sensor
Unmet Need Gene expression is highly regulated through the addition of chemical modifications to RNA molecules. One such modification is methylation of adenosine residues to form m6A, a modified nucleotide which is found in thousands…