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Adoptive T-cell immunotherapy to treat cancer caused by Epstein-Barr virus
Unmet Need Epstein-Barr virus (EBV) is an infectious disease that has been shown to cause a number of cancers originating from EBV-afflicted cells. Across the globe, EBV is associated with approximately 200,000 cases of malignancies…
EEG-based monitoring of brain recovery following stroke
Unmet Need Stroke is the third leading cause of disability in the US, affecting 800,000 annually. Stroke occurs when blood supply to the brain is impeded, leading to brain damage. Currently, recovery from stroke is…
Therapy for neurotensin positive cancers
Unmet Need Under normal conditions, neurotensin signaling is largely constrained to the nervous system. However, abnormal expression is seen in cancers that are aggressive or have a poor prognosis such as pancreatic, which has a12.5%…
Targeted delivery of gene therapy for cardiac injury treatment
Unmet Need After experiencing a heart attack, the adult human heart has no capacity to regenerate lost or damaged cardiac myocytes. This results in severely reduced heart function and eventually heart failure. There are more…
Extracellular vesicle biomarkers for detecting severity and progression of knee osteoarthritis
Unmet Need Osteoarthritis (OA) is a chronic degenerative joint disease that can impact the hands, knees, neck, lower back, and hips, leading to pain and restrictive mobility from the breakdown of connective tissue in these…
A computer vision approach for molecular subtyping of breast cancer using MRI
Unmet Need Breast cancer is the second leading cause of cancer-related deaths in American women and the fourth most common cause of all cancer-related deaths in the U.S. While early screening for cancer using magnetic…
Method and system for evaluating stability of cardic propagation reserve
Unmet Need About 325,000 people in the United States die from sudden cardiac death (SCD) caused by ventricular tachyarrhythmias (VT) each year. When a patient experiences VT, the lower chamber of their heart beats faster…
Transcriptional alterations during blood storage to monitor stored red cells and reduce storage-lesions
Unmet Need Currently, red blood cell (RBC) testing focuses on factors such as hemoglobin content, RBC count, blood typing, and antibody content. These tests, though comprehensive, do not measure the health and quality of RBCs.…
ECG rhythm database
Invention Summary Duke inventors have developed a database of digital 12- lead ECG samples that represent key rhythms of cardiac disorders. Each patient’s disorder was validated by a licensed and board-certified cardiovascular medicine physician to…
Data quality assurance framework for machine learning in healthcare
Unmet Need Currently, larger clinical datasets and electronic health records are fraught with unstandardized parameters and invalid datapoints that can cascade in downstream analyses. Such errors have a 92% incidence rate. These errors would be…
Multiscale coherence imaging for assessing epithelial tissue health in precancerous detection
Unmet Need Epithelial cells act as the body’s first line of defense against foreign elements and are constantly being replaced by newly grown cells. Due in part to these factors, 90% of all cancers originate…
Surgical needle for real-time electromagnetic navigation in trigeminal rhizotomy
Unmet Need Trigeminal neuralgia (TN) is a debilitating disorder that involves severe and recurring facial pain caused by irritation of the trigeminal nerve. Percutaneous trigeminal rhizotomy (PTR) is a preferred treatment for TN because it…