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A method to increase the durability and lifespan of commercially available soft polymer networks
Unmet Need Soft polymers are used for a variety of products including biomedical implants, footwear, and tires. Having a more durable polymer product will increase not only the lifespan of the product but also the…
Novel epigenetic therapy for Prader Willi Syndrome
Unmet Need Prader-Willi Syndrome (PWS) is a rare and complex genetic disorder affecting an estimated 1 in 10,000 to 30,000 infants. Primarily caused by a paternal chromosome 15q11-q13 deletion, PWS presents a myriad of physical,…
Probiotic-based prevention of respiratory infections
Unmet Need Pneumonia is the leading infectious killer of children, causing over 800,000 deaths annually. Streptococcus pneumoniae remains a major driver of these fatalities, even with widespread vaccination. Current vaccines are insufficient to address all…
Small molecules that can safely exploit copper as an antimicrobial
Value Proposition The fungal pathogen Cryptococcus neoformans can live in both plants and animals, but when inhaled by humans can disseminate from the lungs to the bloodstream and cause life-threatening systemic disease. The brain is…
Gene therapy for ATP1A3-Related Neurologic Disorders
Unmet Need Alternating Hemiplegia of Childhood (AHC) is a rare neurologic disorder affecting children, causing episodes of temporary paralysis, dystonia, and severe behavioral issues, with prevalence estimates ranging from 1 in 1 million to 1…
Innovative bispecific T cell engager targeting phosphatidylserine for solid tumor immunotherapy
Unmet Need While cancer immunotherapy has revolutionized treatment of leukemias and lymphomas in recent years, its application to solid tumors has lagged. The reasons for reduced efficacy of CAR-T cells against solid tumors is an…
Temporally Dependent Iterative Expansion (TEDIE), a novel algorithm that accurately identifies seizure-causing epileptic zones in the brain
Unmet Need Epilepsy is one of the most common neurological conditions, affecting approximately 50 million people worldwide as of 2023. Patients with epilepsy face a risk of premature death up to three times higher than…
Personalized Behavioral Risk Prediction Technology
Unmet Need Daily environments significantly influence mental and physical health, impacting factors like stress, sleep quality, and behaviors tied to addiction and mental health conditions. For example, specific environments may trigger smoking, exacerbate insomnia, or…
Optimized hard-decision decoding for generalized product codes in high-speed communication systems
Unmet Need Communication channels often introduce errors due to noise, leading to the need for robust error control mechanisms. While techniques like forward error correction (FEC) add redundant bits to detect and correct transmission errors,…
Antigenome Platform: An autoantigen discovery pipeline
Unmet Need The human body contains approximately 60 trillion antibodies per microliter of blood in circulation, creating a vast and complex network of immune interactions. Identifying the targets of this plethora of antibodies is a…
Real-time monitoring and intervention of specific behaviors by simultaneous recordings of multiple brain regions
Unmet Need There is a need for more effective and precise methods to predict and regulate neurological behaviors, such as aggression, in mammals. Current treatments and behavioral interventions often fail to accurately prevent the onset…
Precision Engineering of Neural Circuits via Designer Connexins for Long-Term Cellular Integration
Unmet Need Gap junctions are crucial for enabling the direct flow of ions and small molecules between cells, playing a significant role in synchronizing electrical activity in organs like the heart and brain. However, mutations…