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C-nitroso donors of neutral nitric oxide to treat hypertension and other diseases

C-nitroso donors of neutral nitric oxide to treat hypertension and other diseases

Value proposition Hypertension, also known as high blood pressure, can lead to severe complications and increase the risk of heart disease, stroke, and death. About 1 out of 3 US adults, or about 75 million…

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Acoustic lens for shockwave lithotripsy

Acoustic lens for shockwave lithotripsy

Systems and methods for providing therapeutic shock waves are provided. A modified acoustic lens can include a first lens portion for directing a first part of an acoustic shock wave pulse toward a target and…

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Composition and methods of multi-targeted siRNA cocktail for treatment of Glioblastoma Multiforme

Composition and methods of multi-targeted siRNA cocktail for treatment of Glioblastoma Multiforme

Value Proposition Glioblastoma is the most common primary malignant brain tumor in adults, and the prognosis of this disease is dismal, despite aggressive standard-of-care therapy with chemoradiation and gross tumor resection. Several molecular mechanisms are…

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Tunable metamaterial

Tunable metamaterial

Technology Metamaterial comprising a plurality of resonators disposed on a substrate, the substrate comprising a dielectric support layer and a relatively thin semiconductor layer, having a Schottky junction between at least one conducting resonator and…

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Automated segmentation of layered structures such as retinal layers using graph cuts

Automated segmentation of layered structures such as retinal layers using graph cuts

Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes connected together by edges.…

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XCAT phantom CT projector

XCAT phantom CT projector

The XCAT, MOBY, and ROBY phantoms include a great amount of anatomical detail that make them suitable for use in high-resolution CT imaging research. To simulate CT imaging process, we developed a CT projector that…

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Conjugated neuroactive steroid compositions and methods of use thereof

Conjugated neuroactive steroid compositions and methods of use thereof

The present disclosure provides modified neuroactive steroids. The modified neuroactive steroids may comprise, consist of, or consist essentially of a therapeutic agent and/or a modifying moiety. The modified neuroactive steroid can have modified characteristics as…

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Detailed brain model for imaging research

Detailed brain model for imaging research

The XCAT brain phantom program includes a highly detailed anatomy for the human brain. Over 100 structures and vessels are modeled based on MRI data. The program will generate voxelized versions of the brain at…

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XCAT library of anatomical models for CT imaging research

XCAT library of anatomical models for CT imaging research

In addition to the standard male and female adult anatomies of the XCAT, we also developed several other models based on CT imaging data. Each model includes the same amount of detail as the original…

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Techniques for the segmentation of layered structures using graph theory and dynamic programming

Techniques for the segmentation of layered structures using graph theory and dynamic programming

Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes connected together by edges.…

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Molecular classifiers of bacterial infection

Molecular classifiers of bacterial infection

Disclosed herein are biomarkers useful for identifying and/or classifying bacterial infections in a subject.

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Method for treating glycogen storage disease

Method for treating glycogen storage disease

The present disclosure is directed to methods of treating a cytoplasmic glycogen storage disorder, including glycogen storage disease I, glycogen storage disease III, glycogen storage disease IV, and/or conditions associated with a PRKAG2 mutation, by…

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