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RNA aptamers for thrombi imaging
Value Proposition Thrombosis (blood clots within blood vessels) is a major underlying factor in many cardiovascular diseases and a major source for complications following hospital stays and surgeries. Venous thrombosis occurs in approximately 1 per…
Discovery of a potent and selective inhibitor of DAPK1 and ZIPK
Value Proposition The DAPK family, including Zipper-interacting protein kinase (ZIPK), mediates cell death through the transmission of apoptotic and autophagic signals. This family of kinases also regulates both non-muscle and smooth muscle myosin phosphorylation. Another…
Novel mutation-resistant smoothened inhibitors for cancer therapy
Value Proposition The hedgehog signaling pathway is an important mediator of developmental and cellular differentiation processes in both embryonic and adult tissues, but can also promote tumor growth and progression if dysregulated. Two forms of…
Methods and compositions for the identification of insect repellent compounds
Value Proposition Insect vector-borne infectious diseases are a major public health threat to both developing and industrialized nations. Though many insects may transmit disease, mosquitoes of of the Aedes and Anopheles genus are particularly known…
Pupil tracking for motion corrected ophthalmic optical coherence tomography
Value proposition Optical Coherence Tomography (OCT) is the standard of care used in diagnosis as well as following the treatment of several pathological ophthalmic conditions. Volumetric acquisition with anterior segment optical coherence tomography (ASOCT) is…
Inhibition of endosomal TLR-activation with nucleic acid binding polymers
Value Proposition Inflammatory and autoimmune diseases are the result of improper activation of the immune system, and can have chronic debilitating effects on quality of life. This inflammation is mediated by pattern recognition receptors (PRRs)…
Ex vivo scavenging of pro-inflammatory nucleic acids by electrospun cationic nanofibers
Value proposition Chronic wounds are a challenge to treat and consume a great deal of healthcare resources around the globe. In the setting of chronic wounds, dead and dying cells are continuously releasing nucleic acids…
RNA Aptamers Targeting a coagulation Cascade Cofactor
Value Proposition Thrombosis (blood clots within blood vessels) is a major underlying factor in many cardiovascular diseases and a major source for complications following hospital stays and surgeries. Venous thrombosis occurs in approximately 1 per…
Controlling coagulation with aptamer combinations and aptamer-drug combinations and their antidotes
Value Proposition Millions of Americans have received anticoagulative agents to prevent pathological blood clot formation (thrombosis). For decades, warfarin and heparin have been the centerpiece of anticoagulative treatment. In the past decade, new anticoagulative agents…
Aptamers to Glycoprotein VI
Value Proposition Millions of Americans have received antiplatelet agents to prevent pathological blood clot formation (thrombosis). Platelets are the key prothrombotic element, forming aggregates that lead to blood clots. Antiplatelet therapies can counteract this process.…
Enhancing of homing and/or engraftment of cord blood mononuclear cells in the central nervous system
Value Proposition Leukodystrophies are inherited disorders resulting in decreased motor function, muscle rigidity, degeneration of sight and hearing, and are ultimately fatal. There is a great lack of treatment, although cord blood mononuclear (CBM) and…