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Gene targeting to the ROSA26 locus
Plasmids for gene modification unitlizing zink finger sequences targeting ROSA locus. Publication: P Perez-Pinera, DG Ousterout, MT Brown, CA Gersbach. Gene Targeting to the ROSA26 Locus Directed by Engineered Zinc Finger Nucleases. Nucleic Acids Res…
Novel dystonia treatment drugs
Value Proposition Dystonia is a movement disorder characterized by sustained, often painful involuntary postures, causing motor disabilities and a marked decrease in quality of life. Dystonia is the third most common movement disorder behind Parkinson’s…
Replication competent bi- and tri-valent influenza viruses as vaccines
Value Proposition Influenza infection is a major public health concern, with an estimated 200,000 Americans hospitalized each year with flu or flu-related illness. The most effective method for flu prevention is vaccination, however, due to…
A humanized mouse model of Duchenne Muscular Dystrophy
This is a novel mouse model containing the full length human dystrophin gene harboring a mutation that models the cause of Duchenne muscular dystrophy. No mouse dystrophin is made, such that therapeutics focused on correction…
Real-time optical coherence tomography processing software
Value Proposition Optical coherence tomography (OCT) has revolutionized retinal diagnostics and is rapidly expanding into surgical settings. Currently, surgical OCT systems are limited to visualization of 2D images of live surgery. This resulted in difficulties…
Endoscopic optical assessment of tissue histology
Value Proposition Endoscopy is an extremely important and prevalent procedure for the diagnosis of a variety of disorders affecting the esophageal and gastrointestinal tracts such as colorectal cancer, adenoma, inflammatory bowel disease, and intestinal metaplasia.…
An effective FASN inhibitor
Value Proposition Many tumors are dependent on de novo fatty acid synthesis as a source of long chain fatty acids to maintain growth and interdicting at key steps in this pathway may have therapeutic benefit.…
Systems and methods for ophthalmic surgical microscope mounted optical coherence tomography
Value Proposition Surgical visualization has changed drastically since its inception, incorporating larger, more advanced optics toward increasing illumination and field-of-view (FOV). However, the limiting factor in vitreoretinal surgery remains the ability to distinguish between tissues…
Passive pressure sensor
Value proposition Monitoring Intracranial Pressure (ICP) in patients undergoing neurological conditions is critical in tracking progress and recovery. In conditions such as hydrocephalus, a shunt is used to allow extra cerebrospinal fluid to drain. These…
Model-based optimization of spinal cord stimulation parameters
Value Proposition Spinal cord stimulation (SCS) is an FDA approved therapy for treating chronic lower back and limb pain. SCS is based on the gate control theory of pain, where an implanted pulse generator delivers…