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Real-time optical coherence tomography processing software
Value Proposition Optical coherence tomography (OCT) has revolutionized retinal diagnostics and is rapidly expanding into surgical settings. Currently, surgical OCT systems are limited to visualization of 2D images of live surgery. This resulted in difficulties…
Endoscopic optical assessment of tissue histology
Value Proposition Endoscopy is an extremely important and prevalent procedure for the diagnosis of a variety of disorders affecting the esophageal and gastrointestinal tracts such as colorectal cancer, adenoma, inflammatory bowel disease, and intestinal metaplasia.…
An effective FASN inhibitor
Value Proposition Many tumors are dependent on de novo fatty acid synthesis as a source of long chain fatty acids to maintain growth and interdicting at key steps in this pathway may have therapeutic benefit.…
Systems and methods for ophthalmic surgical microscope mounted optical coherence tomography
Value Proposition Surgical visualization has changed drastically since its inception, incorporating larger, more advanced optics toward increasing illumination and field-of-view (FOV). However, the limiting factor in vitreoretinal surgery remains the ability to distinguish between tissues…
Passive pressure sensor
Value proposition Monitoring Intracranial Pressure (ICP) in patients undergoing neurological conditions is critical in tracking progress and recovery. In conditions such as hydrocephalus, a shunt is used to allow extra cerebrospinal fluid to drain. These…
Model-based optimization of spinal cord stimulation parameters
Value Proposition Spinal cord stimulation (SCS) is an FDA approved therapy for treating chronic lower back and limb pain. SCS is based on the gate control theory of pain, where an implanted pulse generator delivers…
Construction of patient specific 3D hemodynamic models through 2D angiograms for diagnosis and prognosis of atherosclerosis
Value Proposition Atherosclerotic Cardiovascular Disease is the leading cause of death globally. By some accounts, it claims as many as 17.3 million lives every year. Current diagnostic tests such as CT Angiography and Coronary angiography…
Multicompartment interventional wire and catheter storage basin
Value Proposition Catheters are hollow tube-like medical devices that can be inserted into blood vessels, ducts or body cavities. Catheters are ubiquitously used for the drainage of fluids, the infusion of fluids or the insertion…
Arbitrary viewpoint robotic manipulation
Value Proposition Real-time 3D imaging via tools such as OCT, 3D Ultrasound, and fast MRI/CT allow a surgeon to view the subject of interest from multiple perspectives, including those that are otherwise physically impossible. The…
Shank3 knockout mice as a model for autism
The Shank3B- knockout allele has a neo cassette replacing the PDZ domain (exons 13-16) of the Shank3 gene, resulting altered expression of the Shank3b isoform. These mice may be useful for studying behavioral abnormalities associated…