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Unstructured non-repetitive polypeptides as a tool for imparting temperature-dependent physical properties to protein fusions
Value Proposition Proteins can be useful therapeutic agents when engineered for specificity and selectivity for a clinical target. Their complexity, versatility, tolerability, and diversity often make them superior alternatives to small molecule drugs, and the…
Improving visualization during ultrasound-guided needle insertions
Value Proposition Insertion of needles into blood vessels is a common and crucial intervention for insertion of venous and arterial catheters, as well as blood sampling. Similarly, insertion of needles into tumors and other tissues…
Components of the Wnt-Beta-catenin paracrine signaling pathway as predictive biomarkers for cancer immunotherapy
Value Proposition Immunotherapy is a promising approach for the treatment of many cancers. However, despite early success, majority of patients with advanced cancer fail to respond or become resistant. In even the most immunogenic cancer…
A deep machine learning algorithm to aid the diagnosis of cardiac transplant rejection
Value Proposition Transplant rejection remains a significant clinical concern following solid organ transplants, including cardiac transplantation. Although endomyocardial biopsy to diagnose cardiac allograft rejection is the gold standard of histologic grading of biopsy samples for…
RealChoices web-based menu planning and nutrition tracking computer software program
Value Proposition There are variable reasons why someone would seek a heathier food-related lifestyle. Unhealthy eating habits can have serios negative effects in one’s health. In America alone, it is estimated that over two-thirds of…
A fluorescent probe for monitoring beta-secretase activity in cells
Molecular probes are provided for use in fluorescence microscopy procedures for monitoring beta-secretase enzyme (BACE) activity in living cells and organisms. The probes may be useful for monitoring Alzheimer's Disease-associated BACE in living cells. By…
A software for more easily monitoring physiological data through improved visualization and machine learning analysis
Value Proposition With inexpensive wearable sensors, physiological data monitoring has extended beyond clinical anesthesia and emergency medicine and into in-home healthcare. Waveforms such as electrocardiography (ECG) and photoplethysmography (PPG) contain valuable information about a patient’s…
Antimicrobial prochelators to target drug-resistant bacteria
Value Proposition According to the CDC, each year 2.8 million people in the United States develop an antibiotic-resistant infection, leading to more than 35,000 deaths. Beta lactams were the largest segment in the antibiotics market…
Patient-centric mobile data-architecture for electronic health records
Value Proposition Most Electronic Health Records (EHR) solutions available today are centered around the needs of healthcare providers, in that they allow providers to manage records of their patients. Moreover, they rely on centralized data…
Pharmacometabolomic for drug response phenotypes in the study of cardiovascular disease and its treatment
The present invention concerns the application of lipidomics to statin treatment for disorders such as cardiovascular disorders. Hence, the invention provides, among other things, a method of correlating a lipid profile with a positive or…
Dopamine transporter knockout mouse
We have developed knockout mice lacking the dopamine transporter. These mice are hyperactive, and display cognitive abnormalities consistent with enhanced dopaminergic neurotransmission. They have a heightened dopaminergic state (increase dopamine activity), mimicking certain behaviors associated…
Targeting novel cytokine receptors for anti-cancer activity on human cancers
Researchers at Duke University have discovered novel mRNA isoforms of a cytokine receptor that are expressed in a variety of cancers, including breast and cervical cancer cells. They have created cell lines expressing these abnormal…