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Swipe-to-Locate: Enhancing Real-World Object and Event Localization
Unmet need Conventional techniques for mapping the location of real-world objects or events are successful at identifying the location of static objects at a gross level. Mobile devices such as smartphones typically include GPS for…
Solvent Free Resorbable Resin for 3D Printing
Unmet Need Biologically resorbable resins have allowed for incredible advances in 3D printed implantable device technology. Bone implants, stents, drug delivery scaffolds, and many other lifesaving devices can be custom printed to meet a patient’s…
HIV treatment and prevention using broadly neutralizing antibodies
Unmet Need For over 40 years, the HIV pandemic has affected millions, reducing life expectancy and quality of life. As of 2021, 38.4 million people globally are living with HIV, with about 1.5 million new…
Dark-Blood Delayed-Enhancement MRI: Improved Tissue Contrast and Blood-Pool Signal Suppression
Unmet Need Delayed-enhancement MRI (DE-MRI) is the standard for imaging myocardial infarction (MI), providing high-resolution maps of infarcted and viable myocardium. However, DE-MRI often suffers from poor differentiation between infarcted myocardium and the bright left…
Method for immune tolerance induction in patients receiving enzyme replacement therapy for a variety of metabolic disorders
Unmet Need Genetically based metabolic disorders affect 1 in 2500 births globally and many of these disorders result in an enzyme deficiency. In most cases, a single enzyme is not produced by the body at…
MRI method for detecting partial fatty tissue infiltration within the body
Unmet Need Through magnetic resonance imaging (MRI), it is possible to image and differentiate tissues and biological elements throughout the body. However, due to some tissues of the body having similar chemical compositions and subsequent…
Novel epigenome editors for multiplexed gene regulation
Unmet Need Epigenome editors activate or inhibit gene expression without modifying the underlying DNA sequence. Consequently, these editors can reversibly fine-tune gene expression without the risk of permanently altering the genome or off-target editing. Epigenome…
Novel Method for Treating Steatosis-Associated Diseases
Unmet Need Steatosis-associated diseases are marked by the infiltration of the liver with fatty acids. Liver steatosis occurs in nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), as well as rare diseases such as…
Acoustofluidic technologies for precision control in microfluidic systems
Unmet Need Achieving precise manipulation of particles, cells, and droplets in microscale liquid systems is a major challenge in life sciences, material sciences, and chemistry. Traditional microfluidic systems, which use hydrophobic channels and pressure differentials…
Surface acoustic wave based separation techniques
Value Proposition Complex biofluids such as blood, urine etc. contain a plethora of particles of interest that are of diagnostic and research interest. Examples of such particles may include exosomes, or Circulating Tumor Cells (CTC).…
Digital acoustofluidics: contactless liquid handling device via acoustic streaming
Value Proposition For decades, scientists have pursued the goal of performing automated reactions in a compact fluid processor with minimal human intervention. Digital microfluidics (DMF) pioneers an appealing solution for economical automation by programmable manipulation…
Method to trap and transport small particles with acoustic forces
Value Proposition Acoustic tweezers use ultrasound to create radiation force potential wells that enable precise and contact-free manipulation of physical and biological objects across a broad object size range. It is a fast-developing platform that…